"How to increase dopamine?"
I've heard that statement many times now, with good reason. No neurotransmitter - i.e. brain signaling substance - has been studied as much as dopamine.
You may think that I'd suggest a couple of dopamine pills or supplements and that you're golden.
But it's not that easy...
This blog post why dopamine matters. The next installment of this series considers how to increase your dopamine levels. The "why" question is perhaps even more important than the "how" question.
So why would you increase your dopamine levels? Simple: you'll achieve more, have better abstract and outside the box thinking skills, become more visionary, motivated, and strategic, and will handle pressure better.
These qualities help massively in modern life.
Many people either have low dopamine levels or a disregulated dopamine system in the brain (due to addiction, for example).
Some individuals have very high dopamine and can achieve a lot if they want to. So boosting dopamine sounds great, right?
Many great thinkers of the past actually had high dopamine levels.
Isaac Newton, Aristotle, Bill Gates, Nikola Tesla, Elon Musk, and Albert Einstein come to mind. Of course, no medical studies exist definitively linking their behavior to high dopamine levels.
But their behavior is "hyperdopaminergic" - i..e characteristic of having high dopamine levels.
You can move your level of thinking and motivation into that direction too. Dopamine does not necessarily lead to "happily ever after" though. The neurotransmitter has a dark side.
Excessive dopamine levels decrease empathy while increasing aggression. If you push dopamine even higher, hallucinations, an exaggerated perception of being able to control events, religious experiences, and delusions of grandeur can result.
(Of course, religious experiences are usually not "bad".)
Pushing dopamine levels too high can thus have side-effects. So instead of suggesting you pop a few pills, reality is far more complex.
"What laws govern the universe and how can I use these laws to my advantage"
- a dopamine-driven question.
But do you want to know a secret?
Dopamine is truly essential to what makes human beings human. You've got far higher dopamine levels than your primate ancestors that lived in the jungle.
The short version of the story of human evolution involves that your human ancestors had:
I'll tell the exhilarating story of how humans became more dopaminergic in evolution in the full blog post...
If you don't like that explanation, skip to section 3 below, where I talk about the benefits of dopamine. Again, the next installment tells you how to boost your levels with nutrients, lifestyle changes, supplements, and medication.
Want to get my top-10 dopamine management laws immediately?
You're hearing those sayings everywhere: "boost your dopamine levels".
"High dopamine helps you think outside the box"
"Don't understand me? Your dopamine levels must be low"
"Get sunlight to boost dopamine. You'll feel great and crazy motivated"
And you know what?
There's truth to these statements...
Dopamine does affect your thinking. Dopamine does affect your mood. Dopamine does affect motivation...
In fact, dopamine is of fundamental importance in determining whether your brain works well or not.
But before I'll tell you how to increase your dopamine levels, I'll first want to explain why dopamine matters.
If you don't understand why you're raising your dopamine levels it becomes much harder to get good results.
So if you're simply taking dopamine-enhancing supplements you're making a big mistake - there's no way to correctly interpret outcomes. Why? You don't know what to expect and don't have an understanding of what's happening in your body.
You'll want to use natural dopamine boosters because they make your life better, not because you've read somewhere that taking a supplement is good.
An analogy to demonstrate why understanding is important?
Say you're saving $500 per month to buy a house. You're moving 500 bucks from your paycheck to your savings account every single month. Just save and wait until you can buy a house, right?
That's all - no second thoughts.
Nothing more to it...
You could almost certainly use that $500 much more efficiently if you'd knew about real estate prices in different geographical areas, how the national housing market is trending, and what other investment options bring you.
Maybe the stock market will give you 5% yearly returns on your investment compared to a mere 1% for a savings account. Renting until house prices come down, moreover, might save you 30% on the total price.
Having contextual information around the goal you're trying to accomplish thus helps.
Analogously, let's say you take pills to increase dopamine. But maybe you've already got high levels. In that case, you've just made your life, motivation, and thining ability worse off.
So this blog post series not only teaches you how to increase your dopamine levels naturally but also gives you the context to understand the process.
In this section as well as two subsequent ones I'll therefore consider:
So let's start with the obvious:
The hormone "testosterone" is circulating through the bloodstream and helps develop primary sex characteristics in men. Testicles are an example.
The neurotransmitter "GABA" makes you calm and relaxed. Adrenaline wakes you up.
And dopamine is essential for proper brain and bodily functioning. Without dopamine, you'll literally become mentally disabled.
But what's that neurotransmitter specifically good for?
Dopamine is extremely central to what makes humans "human".
When I discussed dopamine before, I typically write that it helps motivation, assertiveness, and well-being.
That description is only part of the story though. Executive function may be even more important in relation to dopamine. Executive function is one effect that I've not highlighted in detail before:
Executive functions are higher-level thinking abilities. Executive functions include planning, focusing, and entertaining abstract ideas. Dopamine plays a major role in establishing these functions.[9; 10]
Executive function is a strongly human-specific trait.
You probably know that the human brain is truly special in terms of its ability.
And that's true.
So you may assume that grammar, art, symbol usage in mathematics, the written word, and ascribing intentions to others are typically human endeavors.
But in that case, you'd be wrong.
Well, bird songs exhibit grammar and primates can paint and do (simple) math.
In a sense, the human brain is thus less special than you'd think. None of the aforementioned qualities are typically human. except for using mathematical symbols perhaps.
What does make your human cognitive abilities special is that you're able to entertain abstractions of thought. Abstractions or ideas occur independently of sensory context (i.e. empirical circumstances).
Imagining the geometrical properties of a cylinder is an example of an abstraction. No bird or monkey has exhibited that quality (yet).
Only humans can run thought experiments separate from time and space in their minds. Dopamine grounds that process.
A mere 1% of brain cells are actually involved with dopamine functioning though. That 1% is very important, as it makes us quintessentially human. Small changes in brain development can thus have huge effects in your thinking ability, which the 1% demonstrates.
So let's consider how dopamine affects your brain:
Many of the drugs that people take for psychiatric disorders or Parkinson's disease influence these receptors. Lifestyle changes or supplements that influence dopamine utilize that same mechanism.
To understand how receptors work, imagine that when the dopamine neurotransmitter binds to a receptor, physiological effects occur.
Envision pushing a key on a keyboard. The dopamine receptor is analogous to the key. Dopamine is parallel to your hand. The end result of pushing a key is an output (a physiological effect).
Different dopamine receptors have different effects. The D1 receptor is responsible for the growth of new brain cells among others. D1 and D2 take part in motivational action and the reinforcement of behavior. D5 is more involved with emotion and memory.
No need to remember these receptors though, just remember they exist.
That dopamine is not equally distributed throughout that brain:
Depending on how you count, up to 10 dopaminergic pathways can be found in your brain. Pathways are a means by which brain areas can be affected or activated through the dopamine system.
I'll focus on three main pathways.
Two of these pathways are located around the "cortex". The cortex is located directly under your skull. The cortex has most recently developed in evolution, and built on top of older brain parts such as the midbrain.
The third pathway is located below that cortex, in about in the middle of your head.
The two main dopaminergic pathways that affect the cortex can be viewed in the picture below, and emerge from the lower blue dot. The lower blue dot has 1) a small direct connection to your cortex and; 2) a longer pathway that moves all the way through the brain areas directly under your skull.
I've stipulated these brain areas with golden lines below, and numbered them "1" and "2":
The 3rd pathway is called the "nigrostriatal dopaminergic pathway", and emerges from the second blue dot.
So what are the functions of these dopaminergic pathways? Simple:
The first two systems are part of the "meso-cortical" pathway. The word "meso" stands for "middle" in Greek, and "cortical" signifies the cortex. In plain English, the meso-cortical pathway thus connects the midbrain to the cortex.
The third pathway moves from the midbrain to the "basal ganglia". Those basal ganglia are found just below the cerebral cortex and are highly developed in many other mammals as well.
Contrary to the unique development of the (prefrontal) cortex in humans, the basal ganglia are not radically different in humans and primates.
Now that you know some basics regarding dopamine receptors and pathways, let's consider how the neurotransmitter dopamine is actually created:
These amino acids are found in the highest quantities in meat - a topic I'll get back to. With depleted tyrosine or phenylalanine levels, your brain won't produce (sufficient) dopamine.
In that case, your thinking ability suffers.
Eating the right foods is not sufficient for getting high dopamine levels though. You'll also need high dopamine in relation to other neurotransmitters:
Serotonin and adrenaline are two neurotransmitters of great importance. Serotonin and adrenaline (i.e. epinephrine) are diametrically opposed to dopamine function.
The higher your adrenaline and serotonin levels therefore become, the less well dopamine (generally) functions. If you're chronically stressed with high adrenaline levels, your dopamine levels will thus be lower.
And while adrenaline is regularly considered a stress hormone, arguments exist that the same is true for serotonin as well.
High serotonin and adrenaline levels are not the only reason why you may have low dopamine levels though:
Dopamine is truly central to human brain performance. In a condition called "phenylketonuria", the neurotransmitter cannot be made at all. That absence leads to complete mental retardation.
Even brain damage, such as missing a prefrontal cortex or even an entire half of your brain does not create such an extreme loss in cognitive function if it happens early on in life.
You can thus miss parts of your brain but not dopamine as a neurotransmitter. That outcome demonstrates how massively important dopamine is to human life.
You may think: "great, help me create as much dopamine as possible"
In that case, you'd be mistaken...
Even though dopamine function creates wonderful benefits such as abstract thought, more is not always better:
High dopamine levels are like a kind of femme fatale - she'll eat you alive if you don't stay in control.
She's enticing but highly dangerous...
Or perhaps a dangerous macho man, if you're of the other gender...
Well, higher dopamine levels decrease empathy and increase aggression. Repetitive or compulsive movements, hyperactivity, and tics are other signs of excesses.
If you use drugs that heighten dopamine to unnatural levels, delusions of grandiosity or hallucinations result.
And if you'd equate hallucinations with dreams you'd be partially right. Hallucinations and dreams do have commonalities in that both are imaginative.
Hallucinations happen during the waking state, however, while dreams occur at night. Another difference is that the "choline" neurotransmitter is predominant in regulating dreams, while dopamine is more predominant in hallucinations.
Hallucinations, in a sense, is the maximization of abstract thought - you've completely lost touch with the world of sensory experience.
What's even more interesting is that both dreams and hallucinations are associated with religious experiences. Higher dopamine levels are correlated with spiritual belief, for example. It's mostly the imaginative dopaminergic system that's responsible there, not the logical part.
That outcome should not come as a surprise, as religious belief began roughly 80,000 years ago when human dopamine levels reached a new apex.
Hallucinations caused by excess dopamine?
Excessive dopamine levels may also play a role in several conditions that are on the rise today, such as autism, ADHD, obsessive-compulsive disorder, and schizophrenia.[2-6] Of course, other reasons for these conditions exist as well, but dopamine is likely one of them.
Excess dopamine, on the contrary, leads to restlessness and makes you more extraverted.
Excited to socialize after 3 cups of coffee? Dopamine is responsible.
All these instances show that more dopamine is not always better.
And it's not just excessive dopamine levels that are dangerous - the entire system can also get sabotaged:
Gambling, drugs use, and eating more (junk) food than you need are examples of dopamine motivating you for actions you don't want to be motivated for. Other instances are gaming, watching too much porn, and seeking dangerous thrills.
Dopamine literally creates (irrational) "wants" when it's out of balance. You'll really want junk food, for instance, even though you hate yourself for eating the stuff.
The role of dopamine is so complex and deep that even personality is affected by the neurotransmitter:
Yes, really, dopamine levels affect your personality. A quick detour to help you understand why.
Do you know the "Big Five personality traits"? The Big Five are the gold standard for measuring personality in psychology.
And even if you're not aware of the "Big Five" you probably know the difference between "introversion" and "extraversion".
Introverted people gain energy by spending time by themselves, while extraverted people increase their energy by interacting with other people. Extraversion is one domain of the Big Five, so if you score low on extraversion then you're an introvert (like me).
If you're "closed to experience", you're more factually oriented on this particular world. About 75% of people on this planet are actually what is called "closed to experience". If you're closed to experience you're more prone to talk about your weekly social interactions, facts, and the new stuff you're going to buy.
In other words, you're naturally attuned with your senses and this world.
The remaining 25% have "high openness to experience". With high openness to experience, you're less focused on sensory experience and more interested in ideas. Higher openness to experience makes you more curious, creative and gives you a more active imagination.
With high openness to experience, you're more focused on concepts.
That difference in personality is a major source of miscommunication between people.
If you're closed to experience you'll likely describe your opposites as "dreamy" or "high-flown". If you're open to experience you're more likely to describe your opposites as "short-sighted" or "narrow-minded".
Fortunately, there's no right or wrong in terms of personality.
So yes, if you score high in openness to experience, you're less attuned to your senses. Now you're beginning to understand how openness of experience can be linked to dopamine.
Remember those hallucinations? High dopamine essentially means you're slightly hallucinating all the time because your brain is generating abstract thoughts out of nowhere.
Dopamine is nature's way of creating "controlled madness". The ventromedial dopaminergic pathway is particularly responsible for that effect. Remember that that pathway is intuition-based.
With high levels of dopamine in your lateral-prefrontal dopaminergic system, on the contrary, you may be more likely to be described as a "thinker" instead of a "feeler". You relate to the world through a third-person a-personal perspective, logical, while relating to feelings only secondarily.
I can relate to both.
And the story becomes even deeper...
Dopamine truly affects many parts of the human condition:
Even vision is affected by dopamine. Vision deviates to the clouds, above you, when you tend to think deeply.
That idea of dopamine being linked to the sky or heavens is exemplified in the "stargazer rat". The hyperdopaminergic stargazer rat's vision is fixated upward through extension of the neck muscles.
In humans too, are affected like that animal. I'll get back to this topic in the next section, especially in relation to symbolism. Hint: the dopaminergic vision towards the clouds is "other-worldly".
Dopamine does not just affect your brain though:
Many body parts are affected by dopamine. The neurotransmitter cannot exit the brain (due to a "blood-brain barrier") , and any dopamine found outside the brain is thus created locally.
Blood pressure, salt stores, and fluid dynamics are regulated by dopamine in the kidneys for instance. In the cardiovascular system, the neurotransmitter also affects blood pressure through influencing heart function and stimulates blood flow.
Overall, dopamine thus has many purposes in the body and is first and foremost centrally important to brain function.
Now that you understand the basics of dopamine, let's consider how your ancestors wound up with very high dopamine levels compared to primates.
The main question is, in other words, how did the tons of dopamine get there, allowing your ancestors to develop abstract thought?
Stay tuned to find out why...
Dopaminergic systems are millions of years old but have developed explosively from your primate ancestors to modern humans. Chimpanzees and gorillas are examples of primates.
In this section, I'll consider that evolution and at the end of this section, I'll also trace dopamine functioning through recorded history. Understanding that past allows you to better manage your own dopamine levels because you then grasp the context of a problem.
Disclaimer: I've been extensively influenced by an extraordinary book that tackles the same subject:
While most of the argument in this and previous sections is my own, including all citation of sources, I have liberally borrowed ideas from that book. If you like reading this section, buy the work, as my (somewhat different) depiction does no justice to the depth of that academic treatment.
I also break with the author's theory at several points below, so you'll get a new viewpoint by reading that book.
So let's get started.
I'll begin the story of our human past with our primate ancestors and their transition into humans:
For millions of years, your primate ancestors had lived in the jungle. In that jungle, these ancestors mostly ate plant foods such as fruits and leaves. Chimpanzees and gorillas still do so today.
Around 4+ million years ago, some of these ancestors left that jungle. These ancestors slowly began evolving away from the primate model.
Where exactly the precursors to modern humans went isn't definitively known yet - coastlines and Savannah plains are major hypotheses. Those novel environments brought access to new foods, such as higher quantities of meat and shellfish.[17-22]
Woolly mammoths are an example of animals that were hunted by humans.[29; 30] In fact, mammoths eventually went extinct due to a combination of human overhunting and climate change.
These mammoths contained lots of fat and were therefore prime targets.
Recall that animal foods are important because they contain higher levels of specific amino acids. The "tyrosine" and "phenylalanine" amino acids specifically help build dopamine.
Plant foods alone are not perfect for building high dopamine levels.
Tubers may also have been consumed in small quantities, but probably mostly functioned as a "fallback food". Fallback foods are secondary or tertiary options when highly prized foods are unavailable.
Some modern-day hunter-gatherer societies still conceive of tubers that way today, while others focus more on plant foods. Fruits are also widely eaten by modern hunter-gatherers, when available, so I'm not implying an exclusive reliance on animal foods by any means.
One development a couple of million years ago is certain: animal foods began to be consumed in greater quantities.
Dietary animal foods were thus humanity's first move towards more dopamine development. Those moves didn't end there though...
Transitioning outside the jungle also exposed humans to more sunlight. Sunlight exposure is the second dopamine-increasing change.
Why does that matter?
Sunlight emits ultraviolet light. Ultraviolet light is the type of light that can give you sunburns. The skin is one main mechanisms by which sunlight exposure boosts dopamine.
The human skin contains (or can produce) lots of melanin. Melanin is a compound in your skin that protects you from excessive ultraviolet light exposure from the sun. Melanin is also dependent on the availability of dopamine.[422; 423]
Melanin captures ultraviolet light, and your blood does the same. The ultraviolet light thus penetrates your skin, entering your body. Through that mechanism, sunlight has many physiological effects such as increasing your energy levels.
Light exposure through the eye also has dopamine-boosting effects. Why does that statement matter?
Light penetration in the jungle is minute compared to that of plains or beaches. Trees and other plants block much of the sunlight from reaching your eyes and skin. Your human ancestors thus got exposed to exponentially more sunlight when leaving the trees.
A good place to get sunlight? Not so quick...
Sunglasses didn't exist back then - your eyes were thus necessarily exposed to much more ultraviolet light.
Your ancestors also lost their hair over time, further increasing their exposure to sunlight. Hair blocks sunlight from reaching your skin--the loss of hair thus has the opposite effect.
Early humans additionally began walking on two legs - called "bipedalism". Bipedalism frees up your hands, increasing your ability to use tools. If you walk on four legs such as a gorilla, tool use becomes very complicated.
What exactly caused bipedalism to occur in the first place is not known yet - explanations include better movement efficiency on plains, improved capacity to carry objects (such as killed animals), and lower heat losses (because the sun is perpendicular to the human body at the equator).[35; 36]
Other explanations exist as well.
The dietary changes and sunlight exposure set in a process that was not immediately finished. The choice to exit the jungle steered human evolution for millions of years.
Modern Homo sapiens, the species you're a part of, only emerged 200,000 years ago. Homo sapien's unique brain development finished soon after that.
So let's explore these humans:
Humans are unique because of their spectacular intelligence. Human intelligence has several characteristics:
Most of these brain development resulting in the most abstract modes of thinking only emerged ~100,000 years ago. The written word, as opposed to simpler symbol use, is uniquely human. Mathematics also emerged about 80,000 years ago.
Humans were thus not always as smart as they were today.
Several other human species, such as the Homo habilis and Homo erectus did not have the ability to use complex symbols or abstract thought. The former species lived up until 1,400,000 years ago, while the latter perished 700,000 years ago.
For almost millions of years after leaving the jungle, thinking ability of your ancestors was thus less complex than it is today.
From a human perspective, those 4 million years sounds like a long time. From an evolutionary perspective, however, 4 million years is a blink of an eye.
To place that number into context, life began a whopping 3.7 billion years ago. Humans have thus existed for 0.1% that life is present on earth.
How was that capacity for abstract thought achieved? increased dopamine levels, specifically through sunlight and animal food consumption.. The specialization of brain areas also did:
Hemispheres are "brain parts".
Every human has a left and a right hemisphere. Language, logical thinking, precise calculation, planning, and abstract thinking are typical left brain functions. The right brain focuses more on emotions and the concrete world, such as immediate visual and auditory stimuli.
The left and right hemispheres are thus specialized. And although that specialization process had already started in primates, it has continued and culminated in humans.
Dopamine is uniquely predominant in the left brain hemisphere. And that left hemisphere is intrinsically related to uniquely human traits such as abstract thought.
That specialization of brain parts is called "brain lateralization". In the left hemisphere, that brain lateralization allowed dopamine to be pushed even higher.
Human brain development is specifically skewed towards the left prefrontal cortex. The prefrontal cortex that's precisely the endpoint of the dopaminergic system, is much bigger in human beings compared to chimpanzees or gorillas.
The prefrontal cortex is the brain area involved with planning and abstract thought.
That outcome is no coincidence, as the left brain is also more dopaminergic. The fact that the number of brain cells (neurons) specifically those found in the prefrontal cortex are highly predictive of intelligence is supportive of that claim.
A loss of lateralization or predominance of the prefrontal cortex would thus be devastating to your human thinking ability.
So if you don't understand something and someone tells you that you're "low dopamine", they mean to tell you that a lack of dopamine has caused an impairment in your thinking ability. You're unable to see opportunities or the bigger picture.
Gorillas: specialized in muscular strength instead of maximum brain development
Even more differences exist between humans and primates though:
A brain area called the "striatum", that's integral to dopamine function, is also different between humans and apes.[51; 52; 56] Humans simply have higher dopamine production in that brain area compared to chimpanzees and gorillas.
That brain region is responsible for aiding in decision making, motivation, and complex movement.
(For nerds: enzymes such as "DOPA (3,4-dihydroxyphenylalanine) decarboxylase" and "tyrosine hydroxylase" are responsible for that difference.)
Macaques, interestingly enough, also have that capacity, but great apes lost it. Humans later regained that dopamine boost over chimpanzees and gorillas.
Other neurotransmitters such as choline may have paradoxically less predominant in human brains. Human neurotransmitter evolution over millions of years is thus mostly dopaminergic.
And sure, human brain size grew enormously over that period as well. But brain size alone cannot explain the difference between primates and humans.
Humans have greater brain cell density compared to primates, a higher brain to body weight ratio (especially when corrected for body fat), and the aforementioned increase in lateralization.
Differences abound, even though human and primate brains look somewhat similar on first sight.
More brain cells in the same space equal an upgrade of your brain's "hardware". Your ancestors got that upgrade.
Brain size alone does not even predict intelligence in modern humans. Why? 40-50% size differences exist between equally intelligent humans.
Human brain size today is also smaller than it was 35,000 years ago. Around that time your ancestors reached their peak brain size. Size declined from there. One may still claim that intelligence went up over time, especially around the early 20th century, so brain size by itself is a dangerous metric.
Recall that Homo sapiens achieved their pinnacle of intelligence in Africa about 80,000 - 100,000 years ago. Only then was complex technology used, did religious rituals emerge, and art first appear. Mathematics was discovered around the same time.
That period of the emergence of complex culture is often called the "Big Bang". That Big Bang forever set apart our human species from all previous humans such as the Homo habilis and Homo erectus.
One theory is that shellfish consumption in South Africa drove the final expansion in human brain power.[424-426] One enclave of the Homo sapiens species went south from Ethiopia and returned north later on. After returning to their home of Ethiopia they started populating the rest of the world.
With the Ice Age ending 30,000 years ago, and big game such as giant deer or Mammoths neared extinction. Our fellow living human ancestors, Neanderthals, relied on such foods and may have eaten less fish as well.
Neanderthal survival came under pressure.
Homo sapiens were still able to hunt bigger and fatter animals due to their enormous brain development. That brain development allowed your ancestors to pick out the fattest of deer instead of going for a random kill.
Such kills would have an enormous advantage of providing calorie-rich foods. Predators normally hunt the weakest animal in a group as opposed to the healthiest, because the former is easier to kill.
Eventually, despite some interbreeding with modern humans, Neanderthals went extinct. Homo sapiens were the sole survivor - the world was ours.
All in all, several reasons can thus be found for higher dopamine levels developing in your Homo sapien ancestors:
You may now think the story is over, but nothing could be further from the truth. The story is just getting started...
With civilization, written history continues the story of dopamine's development in human brains:
Civilization did not end the upsurge in dopamine levels, but may paradoxically have increased its predominance, especially during the last few centuries.
Simple: even modern-day hunter-gatherer societies don't pursue distant rewards the way modern society does.
Distant rewards, such as an academic degree or building a company, are associated with (you guessed it) high dopamine levels.
How do I know?
Plenty of US billionaires get up at 5 AM in the morning to increase their status, sense of achievement, and yes: even money.
People living in hunter-gatherer societies don't have that mindset.
Primitive people rarely hoard anything in large quantities, whether it's food or materials possessions. So if you're fed well you'll relax, play, have sex, and wait for the next day to come. In general, hunter-gatherer societies are also more egalitarian than developed countries.
The skillsets in demand in hunter-gatherer societies and today's world are also different. Having good physical fitness, being able to communicate, and tool use are paradigmatic skill sets for hunter-gatherers.
Sure, modern hunter-gatherers have higher dopamine levels than primates, but they don't touch type A personalities living in modern cities.
Getting by in modern societies is becoming highly dependent on dopaminergic qualities, such as logic, outside the box thinking, imagination, strategy, and assertiveness.
Low-paying jobs are low dopamine jobs today. Tool use is now a characteristic of the lower-paying jobs, contrary to their place in hunter-gatherer societies.
(No pun intended at low-paying jobs! I've worked those jobs for years as a teenager and in college!)
Abstract thinking rules modern societies. You can get fabulously rich if you can predict the future with your dopaminergic brain. Just ask yourself, what unknown stocks will still rank high in 2 or 5 years time? If you're ballsy enough to have the answer and win, you can retire.
Such activities have little to do with the "here and now". Dopamine is thus strongly future-oriented.
Even religion has gotten more dopaminergic influences over time.
The multitude of gods that were immanent (such as the God of the earth) in hunter-gatherer societies was replaced by one Transcendent God.
That God resides above us, visually - another dopaminergic gesture.
Religion became hierarchical and otherworldy in civilization as well. Remember that you lose touch of reality with dopaminergic hallucinations.
And only with civilization did the 1% came into existence. Don't get me wrong, I'm in favor of capitalism and against equality of outcome.
Wealth distributions in the modern world, however, are far greater than in hunger-gatherer societies. The developed world has socialism for the rich instead of free markets.
People are very driven for more status, money, and material possessions.
Genetics cannot explain why dopamine became so predominant as a neurotransmitter today. Genetics do not radically change over a few generations, and thus these changes need to be explained through environmental influences.
The gain in dominance of dopamine started with the first civilizations 9,000 BC. Over time, dopamine began to regulate the structure of society with the emergence of written laws, basic property rights, and inheritance.
All these instances emphasize continuous striving.
In the third century AD, statues of Roman Emperors no longer looked below onto their admirers, but started staring at the heavens instead. That change in art coincided with the transition from emperors being "the first among equals" (primus inter pares) to "God and Master" (deus et dominus).
That dopaminergic drive even affects the priorities of societies. Even though wars had also played a role in hunter-gatherer societies, the newly emerging empire's prime purpose became waging war and expanding territory.
So dopamine levels entered a period of self-reinforcement with the advent of civilization, whereby higher and higher levels were needed to get by.
That trend culminates in 21st-century society. Today, fewer and fewer people are living in the present moment than ever the case. Everyone is thinking of their next accomplishment, and people who are content with a basic existence are somewhat looked down upon.
I'm part of that movement as well, sometimes to my own detriment. So dopamine does have a dark side that needs to be controlled.
However, the neurotransmitter has an upside as well. If you can manage your dopamine levels appropriately you can accomplish a lot in this world.
The next step is thus to consider the benefits of having optimal dopamine levels. Dopamine is not all gloom and doom...
In this section, I'll consider all the benefits you'll receive when pushing your dopamine levels up.
I demonstrate why dopamine is so great for personal development and taking charge of your life.
Dopamine literally takes your thinking ability and health to the next level.
The next step in the human dopaminergic explorative drive?
Keep in mind that I've treated side-effects of a dopamine excess in a previous section. All of the described benefits can also be side-effects in certain circumstances.
The end result of boosting your dopamine?
High dopamine in action
You'll become more confident, a calculated risk-taker, and improve your thinking ability. Who doesn't benefit from these qualities in modern society?
Want my top-10 laws for managing dopamine - including strategies not listed in this blog post?
You and I live in a hyperdopaminergic society: achievement, status, and money are praised above all.
Instead of blindly accepting such a society or rejecting it completely, a balance should be found.
Many people actually have low dopamine levels, because of which they can no longer see connections between events in their lives. Such people's thinking becomes shallow, often of no fault on their own.
If your ability to think can get a boost or if you're unmotivated, dopamine is great for you.
Other people have dopamine levels that are too high, leading to excessive ambition at all cost, and low empathy.
Both are dangerous.
Lots of people can be helped by optimizing their dopamine levels. In fact, if dopamine makes us fundamentally human - as in different from primates - then that goal is a lofty one.
And the case can be made that the human being - and it's relationship with dopamine - is still evolving. It's pretty likely that you and I learn to control our dopamine levels over time.
Even now, dopamine is not a side issue you can ignore if you want to make the most of life.
Remember that I've aptly called dopamine the "controlled madness of nature" because it's the source of a healthy imagination and abstract thought. With the right dopamine levels, your cognition and motivation go through the roof.
Want to learn more about dopamine? Then I highly recommend reading The Dopaminergic Mind in Human Evolution and History by Fred H. Previc.
Previc' argument is different than mine, albeit, has many similarities as well. And congrats with reading this entire blog post:
With dopamine, you'll become your own hero. Tread carefully.
The next installment of this series considers all different ways you can increase your dopamine levels.
Want an easy way to boost your dopamine levels tomorrow? Get some Qualia Mind and use discount code FERGUS to save on your order. Qualia Mind contains many dopamine precursors that will help you boost your levels!
This is a post by Bart Wolbers. Bart finished degrees in Physical Therapy (B), Philosophy (BA and MA), Philosophy of Science and Technology (MS - Cum Laude), and Clinical Health Science (MS), and is currently a health consultant.
 Krummenacher P, Mohr C, Haker H, Brugger P. Dopamine, paranormal belief, and the detection of meaningful stimuli. J Cogn Neurosci. 2010 Aug;22(8):1670-81. doi: 10.1162/jocn.2009.21313.
 Pavăl D. A Dopamine Hypothesis of Autism Spectrum Disorder. Dev Neurosci. 2017;39(5):355-360. doi: 10.1159/000478725. Epub 2017 Jul 28.
 Hellings JA, Arnold LE, Han JC. Dopamine antagonists for treatment resistance in autism spectrum disorders: review and focus on BDNF stimulators loxapine and amitriptyline. Expert Opin Pharmacother. 2017 Apr;18(6):581-588. doi: 10.1080/14656566.2017.1308483.
 Kriete T, Noelle DC. Dopamine and the development of executive dysfunction in autism spectrum disorders. PLoS One. 2015 Mar 26;10(3):e0121605. doi: 10.1371/journal.pone.0121605. eCollection 2015.
 Denys D, Zohar J, Westenberg HG. The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J Clin Psychiatry. 2004;65 Suppl 14:11-7.
 Kelsby JP, McGrath JJ, Scott JG. Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience. Translational Psychiatryvolume 8, 2018.
 Diamond A. Executive functions. Annu Rev Psychol. 2013;64:135-68. doi: 10.1146/annurev-psych-113011-143750. Epub 2012 Sep 27.
 Rabinovici GD, Stephens ML, Possin KL. Executive dysfunction. Continuum (Minneap Minn). 2015 Jun;21(3 Behavioral Neurology and Neuropsychiatry):646-59. doi: 10.1212/01.CON.0000466658.05156.54.
 Nieoullon A. Dopamine and the regulation of cognition and attention. Prog Neurobiol. 2002 May;67(1):53-83.
 Mehta MA, Riedel WJ. Dopaminergic enhancement of cognitive function. Curr Pharm Des. 2006;12(20):2487-500.
 Gepshtein S, Li X, Snider J, Plank M, Lee D, Poizner H. Dopamine function and the efficiency of human movement. J Cogn Neurosci. 2014 Mar;26(3):645-57. doi: 10.1162/jocn_a_00503. Epub 2013 Oct 21.
 Takakusaki K. Functional Neuroanatomy for Posture and Gait Control. J Mov Disord. 2017 Jan;10(1):1-17. doi: 10.14802/jmd.16062. Epub 2017 Jan 18.
 Takakusaki K, Habaguchi T, ... Sakamoto T. Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction. Neuroscience. 2003;119(1):293-308.
 Takakusaki K, Saitoh K, Harada H, Kashiwayanagi M. Role of basal ganglia-brainstem pathways in the control of motor behaviors. Neurosci Res. 2004 Oct;50(2):137-51.
 Meder D, Herz DM, ... Siebner HR. The role of dopamine in the brain - lessons learned from Parkinson's disease. Neuroimage. 2019 Apr 15;190:79-93. doi: 10.1016/j.neuroimage.2018.11.021. Epub 2018 Nov 20.
 Hisahara S, Shimohama S. Dopamine receptors and Parkinson's disease. Int J Med Chem. 2011;2011:403039. doi: 10.1155/2011/403039. Epub 2011 Jun 13.
 Mann NJ. A brief history of meat in the human diet and current health implications. Meat Sci. 2018 Oct;144:169-179. doi: 10.1016/j.meatsci.2018.06.008. Epub 2018 Jun 13.
 Williams AC, Hill LJ. Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics. Int J Tryptophan Res. 2017 May 2;10:1178646917704661. doi: 10.1177/1178646917704661. eCollection 2017.
 Helm CW, McCrea RT, ... Hattingh S. A New Pleistocene Hominin Tracksite from the Cape South Coast, South Africa. Sci Rep. 2018 Feb 28;8(1):3772. doi: 10.1038/s41598-018-22059-5.
 Braun DR, Harris JW, ... Kibunjia M. Early hominin diet included diverse terrestrial and aquatic animals 1.95 Ma in East Turkana, Kenya. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10002-7. doi: 10.1073/pnas.1002181107. Epub 2010 Jun 1.
 Steele TE. A unique hominin menu dated to 1.95 million years ago. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10771-2. doi: 10.1073/pnas.1005992107. Epub 2010 Jun 7.
 Marean CW. The transition to foraging for dense and predictable resources and its impact on the evolution of modern humans. Philos Trans R Soc Lond B Biol Sci. 2016 Jul 5;371(1698). pii: 20150239. doi: 10.1098/rstb.2015.0239.
 Lou HC. Dopamine precursors and brain function in phenylalanine hydroxylase deficiency. Acta Paediatr Suppl. 1994 Dec;407:86-8.
 Montgomery AJ, McTavish SF, Cowen PJ, Grasby PM. Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study. Am J Psychiatry. 2003 Oct;160(10):1887-9.
 Ramdani C, Vidal F, ... Hasbroucq T. Dopamine and response selection: an Acute Phenylalanine/Tyrosine Depletion study. Psychopharmacology (Berl). 2018 Apr;235(4):1307-1316. doi: 10.1007/s00213-018-4846-3. Epub 2018 Feb 9.
 Marlowe FW, Berbesque JC. Tubers as fallback foods and their impact on Hadza hunter-gatherers. Am J Phys Anthropol. 2009 Dec;140(4):751-8. doi: 10.1002/ajpa.21040.
 Lewin R. Man the Scavenger: Hominids of 2 million years ago ate meat: but were they hunters or scavengers? A scavenging hypothesis has now been fully articulated. Science. 1984 May 25;224(4651):861-2.
 Ben-Dor M, Gopher A, Hershkovitz I, Barkai R. Man the fat hunter: the demise of Homo erectus and the emergence of a new hominin lineage in the Middle Pleistocene (ca. 400 kyr) Levant. PLoS One. 2011;6(12):e28689. doi: 10.1371/journal.pone.0028689. Epub 2011 Dec 9.
 Agam A, Barkai R. Elephant and Mammoth Hunting during the Paleolithic: A Review of the Relevant Archaeological, Ethnographic and Ethno-Historical Records. Quaternary 2018, 1(1)
 Nogués-Bravo D, Rodríguez J, ... Araújo MB. Climate change, humans, and the extinction of the woolly mammoth. PLoS Biol. 2008 Apr 1;6(4):e79. doi: 10.1371/journal.pbio.0060079.
 Green AC, Kimlin M, Siskind V, Whiteman DC. Hypothesis: hair cover can protect against invasive melanoma on the head and neck (Australia). Cancer Causes Control. 2006 Dec;17(10):1263-6.
 van Schaik CP, Deaner RO, Merrill MY. The conditions for tool use in primates: implications for the evolution of material culture. J Hum Evol. 1999 Jun;36(6):719-41.
 McGrew WC. Is primate tool use special? Chimpanzee and New Caledonian crow compared. Philos Trans R Soc Lond B Biol Sci. 2013 Oct 7;368(1630):20120422. doi: 10.1098/rstb.2012.0422. Print 2013 Nov 19.
 la Cour LT, Stone BW, ... Fragaszy DM. What limits tool use in nonhuman primates? Insights from tufted capuchin monkeys (Sapajus spp.) and chimpanzees (Pan troglodytes) aligning three-dimensional objects to a surface. Anim Cogn. 2014 Jan;17(1):113-25. doi: 10.1007/s10071-013-0643-x. Epub 2013 Jul 3.
 Dávid-Barrett T, Dunbar RI. Bipedality and hair loss in human evolution revisited: The impact of altitude and activity scheduling. J Hum Evol. 2016 May;94:72-82. doi: 10.1016/j.jhevol.2016.02.006. Epub 2016 Mar 22.
 Lequin M. Paleoanthropology's uses of the bipedal criterion. Hist Philos Life Sci. 2017 Nov 22;40(1):7. doi: 10.1007/s40656-017-0172-z.
 Bratsberg B, Rogeberg O. Flynn effect and its reversal are both environmentally caused. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6674-6678. doi: 10.1073/pnas.1718793115. Epub 2018 Jun 11.
 Trahan LH, Stuebing KK, Fletcher JM, Hiscock M. The Flynn effect: a meta-analysis. Psychol Bull. 2014 Sep;140(5):1332-60. doi: 10.1037/a0037173. Epub 2014 Jun 30.
 Bratsberg B, Rogeberg O. Flynn effect and its reversal are both environmentally caused. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6674-6678. doi: 10.1073/pnas.1718793115. Epub 2018 Jun 11.
 Shenk D. What is the Flynn Effect, and how does it change our understanding of IQ? Wiley Interdiscip Rev Cogn Sci. 2017 Jan;8(1-2). doi: 10.1002/wcs.1366. Epub 2016 Dec 1.
 Fuertinger S, Zinn JC, ... Simonyan K. Dopamine drives left-hemispheric lateralization of neural networks during human speech. J Comp Neurol. 2018 Apr 1;526(5):920-931. doi: 10.1002/cne.24375. Epub 2017 Dec 21.
 Simonyan K, Herscovitch P, Horwitz B. Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: a combined PET, fMRI and DTI study. Neuroimage. 2013 Apr 15;70:21-32. doi: 10.1016/j.neuroimage.2012.12.042. Epub 2012 Dec 28.
 Molochnikov I, Cohen D. Hemispheric differences in the mesostriatal dopaminergic system. Front Syst Neurosci. 2014 Jun 11;8:110. doi: 10.3389/fnsys.2014.00110. eCollection 2014.
 Oleksiak A, Postma A, ... van Wezel RJ. A review of lateralization of spatial functioning in nonhuman primates. Brain Res Rev. 2011 Jun 24;67(1-2):56-72. doi: 10.1016/j.brainresrev.2010.11.002. Epub 2010 Nov 6.
 Fitzgerald PJ. Whose side are you on: does serotonin preferentially activate the right hemisphere and norepinephrine the left? Med Hypotheses. 2012 Aug;79(2):250-4. doi: 10.1016/j.mehy.2012.05.001. Epub 2012 May 28.
 Corballis MC. Left brain, right brain: facts and fantasies. PLoS Biol. 2014 Jan;12(1):e1001767. doi: 10.1371/journal.pbio.1001767. Epub 2014 Jan 21.
 Henneberg M. Evolution of the human brain: is bigger better? Clin Exp Pharmacol Physiol. 1998 Sep;25(9):745-9.
 Herculano-Houzel S. The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost. Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1:10661-8. doi: 10.1073/pnas.1201895109. Epub 2012 Jun 20.
 Neubauer S, Hublin JJ, Gunz P. The evolution of modern human brain shape. Sci Adv. 2018 Jan 24;4(1):eaao5961. doi: 10.1126/sciadv.aao5961. eCollection 2018 Jan.
 Cairό O. External measures of cognition. Front Hum Neurosci. 2011 Oct 4;5:108. doi: 10.3389/fnhum.2011.00108. eCollection 2011.
 Sousa AMM, Zhu Y, ... Sestan N. Molecular and cellular reorganization of neural circuits in the human lineage. Science. 2017 Nov 24;358(6366):1027-1032. doi: 10.1126/science.aan3456.
 Raghanti MA, Edler MK,... Lovejoy CO. A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1108-E1116. doi: 10.1073/pnas.1719666115. Epub 2018 Jan 22.
 Smaers JB, Steele J, ... Zilles K. Primate prefrontal cortex evolution: human brains are the extreme of a lateralized ape trend. Brain Behav Evol. 2011;77(2):67-78. doi: 10.1159/000323671. Epub 2011 Feb 17.
 Williams RA, Mamotte CD, Burnett JR. Phenylketonuria: an inborn error of phenylalanine metabolism. Clin Biochem Rev. 2008 Feb;29(1):31-41.
 Herculano-Houzel S. Numbers of neurons as biological correlates of cognitive capability. Current Opinion in Behavioral Sciences 15 2017: 1-7.
 Rapoport SI. Integrated phylogeny of the primate brain, with special reference to humans and their diseases. Brain Res Brain Res Rev. 1990 Sep-Dec;15(3):267-94.
 Henshilwood CS, d'Errico F, ... Wintle AG. Emergence of modern human behavior: Middle Stone Age engravings from South Africa. Science. 2002 Feb 15;295(5558):1278-80. Epub 2002 Jan 10.
 Pagel M. Q&A: What is human language, when did it evolve and why should we care? BMC Biol. 2017 Jul 24;15(1):64. doi: 10.1186/s12915-017-0405-3.
 Tsai HY, Chen KC, ... Lee IH. Sunshine-exposure variation of human striatal dopamine D(2)/D(3) receptor availability in healthy volunteers. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):107-10. doi: 10.1016/j.pnpbp.2010.09.014. Epub 2010 Sep 26.
 Romeo S, Viaggi C, ... Maggio R. Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology. Sci Rep. 2013;3:1395. doi: 10.1038/srep01395.
 Cawley EI, Park S, ... Leyton M. Dopamine and light: dissecting effects on mood and motivational states in women with subsyndromal seasonal affective disorder. J Psychiatry Neurosci. 2013 Nov;38(6):388-97. doi: 10.1503/jpn.120181.
 Castañeda TR, de Prado BM, Prieto D, Mora F. Circadian rhythms of dopamine, glutamate and GABA in the striatum and nucleus accumbens of the awake rat: modulation by light. J Pineal Res. 2004 Apr;36(3):177-85.
 Shieh KR, Chu YS, Pan JT. Circadian change of dopaminergic neuron activity: effects of constant light and melatonin. Neuroreport. 1997 Jul 7;8(9-10):2283-7.
 Khaldy H, León J, ... Acuña-Castroviejo D. Circadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and of melatonin treatment. Neuroendocrinology. 2002 Mar;75(3):201-8.
 Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE. Skin β-endorphin mediates addiction to UV light. Cell. 2014 Jun 19;157(7):1527-34. doi: 10.1016/j.cell.2014.04.032.
 Rosiak J, Zawilska JB. Near-ultraviolet light perceived by the retina generates the signal suppressing melatonin synthesis in the chick pineal gland-an involvement of NMDA glutamate receptors. Neurosci Lett. 2005 May 13;379(3):214-7. Epub 2005 Jan 22.
 Frank MJ, O'Reilly RC. A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol. Behav Neurosci. 2006 Jun;120(3):497-517.
 Kim J, Jang S, ...Kim K. Implications of Circadian Rhythm in Dopamine and Mood Regulation. Mol Cells. 2017 Jul 31;40(7):450-456. doi: 10.14348/molcells.2017.0065. Epub 2017 Jul 31.
 Korshunov K, Blakemore LJ, Trombley PQ. Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System. Front Cell Neurosci. 2017 Apr 3;11:91. doi: 10.3389/fncel.2017.00091. eCollection 2017.
 Verwey M, Dhir S, Amir S. Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease.`F1000Res. 2016 Aug 24;5. pii: F1000 Faculty Rev-2062. doi: 10.12688/f1000research.9180.1. eCollection 2016.
 Freyberg Z, McCarthy MJ. Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances. NPJ Schizophr. 2017 Apr 10;3:17. doi: 10.1038/s41537-017-0018-4. eCollection 2017.
 Huang J, Zhong Z, ... Wang H. Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. J Neurosci. 2015 Feb 11;35(6):2572-87. doi: 10.1523/JNEUROSCI.2551-14.2015.
 Baba K, DeBruyne JP, Tosini G. Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium. Sci Rep. 2017 Jul 11;7(1):5103. doi: 10.1038/s41598-017-05394-x.
 Blum ID, Zhu L, ... Storch KF. A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal. Elife. 2014 Dec 29;3. doi: 10.7554/eLife.05105.
 Jackson CR, Capozzi M, Dai H, McMahon DG. Circadian perinatal photoperiod has enduring effects on retinal dopamine and visual function. J Neurosci. 2014 Mar 26;34(13):4627-33. doi: 10.1523/JNEUROSCI.4887-13.2014.
 Grippo RM, Purohit AM, ... Güler AD. Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment. Curr Biol. 2017 Aug 21;27(16):2465-2475.e3. doi: 10.1016/j.cub.2017.06.084. Epub 2017 Aug 3.
 Volkow ND, Tomasi D,... Ferré S. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. 2012 May 9;32(19):6711-7. doi: 10.1523/JNEUROSCI.0045-12.2012.
 Volkow ND, Tomasi D, ... Swanson JM. Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment. Neuroimage. 2009 May 1;45(4):1232-40. doi: 10.1016/j.neuroimage.2009.01.003. Epub 2009 Jan 20.
 Volkow ND, Wang GJ, ... Jayne M. Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain. J Neurosci. 2008 Aug 20;28(34):8454-61. doi: 10.1523/JNEUROSCI.1443-08.2008.
 Lim MM, Xu J, Holtzman DM, Mach RH. Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum. Neuroreport. 2011 Jul 13;22(10):489-93. doi: 10.1097/WNR.0b013e32834846a0.
 Volkow ND, Wang GJ, ... Pradhan K. Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage. 2008 Oct 1;42(4):1537-43. doi: 10.1016/j.neuroimage.2008.06.002. Epub 2008 Jun 13.
 Monti JM, Monti D. The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev. 2007 Apr;11(2):113-33. Epub 2007 Feb 1.
 Oishi Y, Lazarus M. The control of sleep and wakefulness by mesolimbic dopamine systems. Neurosci Res. 2017 May;118:66-73. doi: 10.1016/j.neures.2017.04.008. Epub 2017 Apr 20.
 Martins RC1, Andersen ML, ... Tufik S. Dopamine transporter regulation during four nights of REM sleep deprivation followed by recovery--an in vivo molecular imaging study in humans. Sleep. 2010 Feb;33(2):243-51.
 Volkow ND, Tomasi D, ... Ferré S. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. 2012 May 9;32(19):6711-7. doi: 10.1523/JNEUROSCI.0045-12.2012.
 Tufik S. Changes of response to dopaminergic drugs in rats submitted to REM-sleep deprivation. Psychopharmacology (Berl). 1981;72(3):257-60.
 Perogamvros L, Schwartz S. The roles of the reward system in sleep and dreaming. Neurosci Biobehav Rev. 2012 Sep;36(8):1934-51. doi: 10.1016/j.neubiorev.2012.05.010. Epub 2012 Jun 2.
 Herrera-Solis A, Herrera-Morales W, ... Arias-Carrion O. Dopaminergic Modulation of Sleep-Wake States. CNS Neurol Disord Drug Targets. 2017;16(4):380-386. doi: 10.2174/1871527316666170320145429.
 Berridge KC. The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl). 2007 Apr;191(3):391-431. Epub 2006 Oct 27.
 Berridge KC, Robinson TE, Aldridge JW. Dissecting components of reward: 'liking', 'wanting', and learning. Curr Opin Pharmacol. 2009 Feb;9(1):65-73. doi: 10.1016/j.coph.2008.12.014. Epub 2009 Jan 21.
 Zabelina DL, Colzato L, Beeman M, Hommel B. Dopamine and the Creative Mind: Individual Differences in Creativity Are Predicted by Interactions between Dopamine Genes DAT and COMT. PLoS One. 2016 Jan 19;11(1):e0146768. doi: 10.1371/journal.pone.0146768. eCollection 2016.
 Wise RA. Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1149-58.
 Bratcher NA, Farmer-Dougan V, ... Garris PA. The role of dopamine in reinforcement: changes in reinforcement sensitivity induced by D1-type, D2-type, and nonselective dopamine receptor agonists. J Exp Anal Behav. 2005 Nov;84(3):371-99.
 Morita K, Morishima M, Sakai K, Kawaguchi Y. Dopaminergic control of motivation and reinforcement learning: a closed-circuit account for reward-oriented behavior. J Neurosci. 2013 May 15;33(20):8866-90. doi: 10.1523/JNEUROSCI.4614-12.2013.
 Glimcher PW. Understanding dopamine and reinforcement learning: the dopamine reward prediction error hypothesis. Proc Natl Acad Sci U S A. 2011 Sep 13;108 Suppl 3:15647-54. doi: 10.1073/pnas.1014269108. Epub 2011 Mar 9.
 Steinberg EE, Boivin JR, ... Janak PH. Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PLoS One. 2014 Apr 14;9(4):e94771. doi: 10.1371/journal.pone.0094771. eCollection 2014.
 Gonzales RA, Job MO, Doyon WM. The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement. Pharmacol Ther. 2004 Aug;103(2):121-46.
 Bao S, Chan VT, Merzenich MM. Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Nature. 2001 Jul 5;412(6842):79-83.
 Green CS, Bavelier D. Exercising your brain: a review of human brain plasticity and training-induced learning. Psychol Aging. 2008 Dec;23(4):692-701. doi: 10.1037/a0014345.
 Thomas MJ, Kalivas PW, Shaham Y. Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol. 2008 May;154(2):327-42. doi: 10.1038/bjp.2008.77. Epub 2008 Mar 17.
 Foley TE, Fleshner M. Neuroplasticity of dopamine circuits after exercise: implications for central fatigue. Neuromolecular Med. 2008;10(2):67-80. doi: 10.1007/s12017-008-8032-3. Epub 2008 Feb 15.
[102[ Matthews RT, Ferrante RJ, ... Beal MF. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol. 1999 May;157(1):142-9.
 Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, ... Wills AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. JAMA. 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120.
 Jardí F, Laurent MR, ... Vanderschueren D. Testosterone boosts physical activity in male mice via dopaminergic pathways. Sci Rep. 2018 Jan 17;8(1):957. doi: 10.1038/s41598-017-19104-0.
 Simpkins JW, Kalra SP, Kalra PS. Variable effects of testosterone on dopamine activity in several microdissected regions in the preoptic area and medial basal hypothalamus. Endocrinology. 1983 Feb;112(2):665-9.
 Purves-Tyson TD, Owens SJ, ... Weickert CS. Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. PLoS One. 2014 Mar 11;9(3):e91151. doi: 10.1371/journal.pone.0091151. eCollection 2014.
 Triemstra JL, Sato SM, Wood RI. Testosterone and nucleus accumbens dopamine in the male Syrian hamster. Psychoneuroendocrinology. 2008 Apr;33(3):386-94. doi: 10.1016/j.psyneuen.2007.12.006. Epub 2008 Jan 30.
 Sinclair D, Purves-Tyson TD, Allen KM, Weickert CS. Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain. Psychopharmacology (Berl). 2014 Apr;231(8):1581-99. doi: 10.1007/s00213-013-3415-z. Epub 2014 Jan 31.
 Majcher-Maślanka I, Solarz A, Wędzony K, Chocyk A. The effects of early-life stress on dopamine system function in adolescent female rats. Int J Dev Neurosci. 2017 Apr;57:24-33. doi: 10.1016/j.ijdevneu.2017.01.001. Epub 2017 Jan 5.
 Cabib S, Giardino L, ... Puglisi-Allegra S. Stress promotes major changes in dopamine receptor densities within the mesoaccumbens and nigrostriatal systems. Neuroscience. 1998 May;84(1):193-200.
 Moriam S, Sobhani ME. Epigenetic effect of chronic stress on dopamine signaling and depression. Genet Epigenet. 2013 Feb 10;5:11-6. doi: 10.4137/GEG.S11016. eCollection 2013.
 Isovich E, Mijnster MJ, Flügge G, Fuchs E. Chronic psychosocial stress reduces the density of dopamine transporters. Eur J Neurosci. 2000 Mar;12(3):1071-8.
 Horger BA, Roth RH. The role of mesoprefrontal dopamine neurons in stress. Crit Rev Neurobiol. 1996;10(3-4):395-418.
 Finlay JM, Zigmond MJ. The effects of stress on central dopaminergic neurons: possible clinical implications. Neurochem Res. 1997 Nov;22(11):1387-94.
 Szczypka MS, Zhou QY, Palmiter RD. Dopamine-stimulated sexual behavior is testosterone dependent in mice. Behav Neurosci. 1998 Oct;112(5):1229-35.
 Siris SG, Siris ES, ... Bunney WE Jr. Effects of dopamine blockade on gonadotropins and testosterone in men. Am J Psychiatry. 1980 Feb;137(2):211-4.
 Campbell BC, Dreber A, ... Lum JK. Testosterone exposure, dopaminergic reward, and sensation-seeking in young men. Physiol Behav. 2010 Mar 30;99(4):451-6. doi: 10.1016/j.physbeh.2009.12.011. Epub 2009 Dec 21.
 Morris RW, Purves-Tyson TD, ... Weickert TW. Testosterone and reward prediction-errors in healthy men and men with schizophrenia. Schizophr Res. 2015 Nov;168(3):649-60. doi: 10.1016/j.schres.2015.06.030. Epub 2015 Jul 29.
 Foreman MM, Hall JL. Effects of D2-dopaminergic receptor stimulation on the lordotic response of female rats. Psychopharmacology (Berl). 1987;91(1):96-100.
 Giuliano F, Allard J. Dopamine and male sexual function. Eur Urol. 2001 Dec;40(6):601-8.
 Melis MR, Argiolas A. Dopamine and sexual behavior. Neurosci Biobehav Rev. 1995 Spring;19(1):19-38.
 Hilton DL, Watts C. Pornography addiction: A neuroscience perspective. Surg Neurol Int. 2011 Feb 21;2:19. doi: 10.4103/2152-7806.76977.
 de Alarcón R, de la Iglesia JI, Casado NM, Montejo AL. Online Porn Addiction: What We Know and What We Don't-A Systematic Review. J Clin Med. 2019 Jan 15;8(1). pii: E91. doi: 10.3390/jcm8010091.
 Laneri D, Schuster V, ... Sommer J. Effects of Long-Term Mindfulness Meditation on Brain's White Matter Microstructure and its Aging. Front Aging Neurosci. 2016 Jan 14;7:254. doi: 10.3389/fnagi.2015.00254. eCollection 2015.
 Kjaer TW, Bertelsen C, ... Lou HC. Increased dopamine tone during meditation-induced change of consciousness. Brain Res Cogn Brain Res. 2002 Apr;13(2):255-9.
 Newberg AB, Iversen J. The neural basis of the complex mental task of meditation: neurotransmitter and neurochemical considerations. Med Hypotheses. 2003 Aug;61(2):282-91.
 Bujatti M, Riederer P. Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique. J Neural Transm. 1976;39(3):257-67.
 Rubia K. The neurobiology of Meditation and its clinical effectiveness in psychiatric disorders. Biol Psychol. 2009 Sep;82(1):1-11. doi: 10.1016/j.biopsycho.2009.04.003. Epub 2009 Apr 23.
 Chiesa A, Serretti A. A systematic review of neurobiological and clinical features of mindfulness meditations. Psychol Med. 2010 Aug;40(8):1239-52. doi: 10.1017/S0033291709991747. Epub 2009 Nov 27.
 Arnsten AF, Rubia K. Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):356-67. doi: 10.1016/j.jaac.2012.01.008. Epub 2012 Mar 3.
 Zou L, Yeung A, ... Wang H. A Systematic Review and Meta-Analysis of Mindfulness-Based (Baduanjin) Exercise for Alleviating Musculoskeletal Pain and Improving Sleep Quality in People with Chronic Diseases. Int J Environ Res Public Health. 2018 Jan 25;15(2). pii: E206. doi: 10.3390/ijerph15020206.
 Amutio A, Franco C, ... Molero-Jurado MDM. Effects of Mindfulness Training on Sleep Problems in Patients With Fibromyalgia. Front Psychol. 2018 Aug 3;9:1365. doi: 10.3389/fpsyg.2018.01365. eCollection 2018.
 Rusch HL, Rosario M, ... Gill JM. The effect of mindfulness meditation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. Ann N Y Acad Sci. 2018 Dec 21. doi: 10.1111/nyas.13996.
 Black DS, O'Reilly GA, ... Irwin MR. Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015 Apr;175(4):494-501. doi: 10.1001/jamainternmed.2014.8081.
 Neuendorf R, Wahbeh H, ... Oken BS. The Effects of Mind-Body Interventions on Sleep Quality: A Systematic Review. Evid Based Complement Alternat Med. 2015;2015:902708. doi: 10.1155/2015/902708. Epub 2015 Jun 16.
 Mavridis IN. Music and the nucleus accumbens. Surg Radiol Anat. 2015 Mar;37(2):121-5. doi: 10.1007/s00276-014-1360-0. Epub 2014 Aug 8.
 Moraes MM, Rabelo PCR, ... Soares DD. Auditory stimulation by exposure to melodic music increases dopamine and serotonin activities in rat forebrain areas linked to reward and motor control. Neurosci Lett. 2018 Apr 23;673:73-78. doi: 10.1016/j.neulet.2018.02.058. Epub 2018 Feb 27.
 Blood AJ, Zatorre RJ. Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11818-23.
 Salimpoor VN, Benovoy M, Larcher K, Dagher A, Zatorre RJ. Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat Neurosci. 2011 Feb;14(2):257-62. doi: 10.1038/nn.2726. Epub 2011 Jan 9.
 Brodal HP, Osnes B, Specht K. Listening to Rhythmic Music Reduces Connectivity within the Basal Ganglia and the Reward System. Front Neurosci. 2017 Mar 28;11:153. doi: 10.3389/fnins.2017.00153. eCollection 2017.
 Moore H, Rose HJ, Grace AA. Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neurons. Neuropsychopharmacology. 2001 Apr;24(4):410-9.
 Srámek P, Simecková M, Janský L, Savlíková J, Vybíral S. Human physiological responses to immersion into water of different temperatures. Eur J Appl Physiol. 2000 Mar;81(5):436-42.
 Ootsuka Y, Heidbreder CA, Hagan JJ, Blessing WW. Dopamine D2 receptor stimulation inhibits cold-initiated thermogenesis in brown adipose tissue in conscious rats. Neuroscience. 2007 Jun 15;147(1):127-35. Epub 2007 May 21.
 Hagelberg N, Martikainen IK, ... Pertovaara A. Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity. Pain. 2002 Sep;99(1-2):273-9.
 Eisenhofer G, Aneman A, ... Mezey E. Substantial production of dopamine in the human gastrointestinal tract. J Clin Endocrinol Metab. 1997 Nov;82(11):3864-71.
 Xue R, Zhang H, ... Bai L. Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis. Front Immunol. 2018 Oct 17;9:2398. doi: 10.3389/fimmu.2018.02398. eCollection 2018.
 Smits SA, Leach J, ... Sonnenburg JL. Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania. Science. 2017 Aug 25;357(6353):802-806. doi: 10.1126/science.aan4834.
 Fragiadakis GK, Smits SA, ... Sonnenburg JL. Links between environment, diet, and the hunter-gatherer microbiome. Gut Microbes. 2019;10(2):216-227. doi: 10.1080/19490976.2018.1494103. Epub 2018 Aug 17.
 Jadhav KS, Peterson VL, ... Boutrel B. Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking. Neuropharmacology. 2018 Oct;141:249-259. doi: 10.1016/j.neuropharm.2018.08.026. Epub 2018 Aug 31.
 Strandwitz P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018 Aug 15;1693(Pt B):128-133. doi: 10.1016/j.brainres.2018.03.015.
 Mittal R, Debs LH,... Liu XZ. Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis. J Cell Physiol. 2017 Sep;232(9):2359-2372. doi: 10.1002/jcp.25518. Epub 2017 Apr 10.
 Tillmann S, Awwad HM, ... Obeid R. Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression. Mol Nutr Food Res. 2018 Apr;62(7):e1701070. doi: 10.1002/mnfr.201701070. Epub 2018 Mar 13.
 Sarkar A, Lehto SM, ... Burnet PWJ. Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals. Trends Neurosci. 2016 Nov;39(11):763-781. doi: 10.1016/j.tins.2016.09.002. Epub 2016 Oct 25.
 Deaver JA, Eum SY, Toborek M. Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition. Front Microbiol. 2018 Apr 13;9:737. doi: 10.3389/fmicb.2018.00737. eCollection 2018.
 Liang X, FitzGerald GA. Timing the Microbes: The Circadian Rhythm of the Gut Microbiome. J Biol Rhythms. 2017 Dec;32(6):505-515. doi: 10.1177/0748730417729066. Epub 2017 Sep 1.
 Voigt RM, Forsyth CB, ... Keshavarzian A. Circadian Rhythm and the Gut Microbiome. Int Rev Neurobiol. 2016;131:193-205. doi: 10.1016/bs.irn.2016.07.002. Epub 2016 Sep 6.
 Paiva I, Pinho R, ... Outeiro TF. Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage. Hum Mol Genet. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114.
 Sharma S, Taliyan R, Singh S. Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: Modulation of histone deacetylase activity. Behav Brain Res. 2015 Sep 15;291:306-314. doi: 10.1016/j.bbr.2015.05.052. Epub 2015 Jun 3.
 St Laurent R, O'Brien LM, Ahmad ST. Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease. Neuroscience. 2013 Aug 29;246:382-90. doi: 10.1016/j.neuroscience.2013.04.037. Epub 2013 Apr 25.
 Wennberg P, Boraxbekk CJ, ... Dunstan DW. Acute effects of breaking up prolonged sitting on fatigue and cognition: a pilot study. BMJ Open. 2016 Feb 26;6(2):e009630. doi: 10.1136/bmjopen-2015-009630.
 Foley TE, Fleshner M. Neuroplasticity of dopamine circuits after exercise: implications for central fatigue. Neuromolecular Med. 2008;10(2):67-80. doi: 10.1007/s12017-008-8032-3. Epub 2008 Feb 15.
 Petzinger GM, Holschneider DP... Jakowec MW. The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry. Brain Plast. 2015;1(1):29-39.
 Greenwood BN. The role of dopamine in overcoming aversion with exercise. Brain Res. 2018 Aug 29. pii: S0006-8993(18)30452-9. doi: 10.1016/j.brainres.2018.08.030.
 Kintz N, Petzinger GM, Jakowec MW. Treadmill exercise modifies dopamine receptor expression in the prefrontal cortex of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease. Neuroreport. 2017 Oct 18;28(15):987-995. doi: 10.1097/WNR.0000000000000865.
 Cordeiro LMS, Rabelo PCR, ... Soares DD. Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems. Braz J Med Biol Res. 2017 Oct 19;50(12):e6432. doi: 10.1590/1414-431X20176432.
 Vučković MG, Li Q, Fisher ... Petzinger GM. Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F]fallypride. Mov Disord. 2010 Dec 15;25(16):2777-84. doi: 10.1002/mds.23407.
 Tajiri N, Yasuhara T, Shingo ... Date I. Exercise exerts neuroprotective effects on Parkinson's disease model of rats. Brain Res. 2010 Jan 15;1310:200-7. doi: 10.1016/j.brainres.2009.10.075. Epub 2009 Nov 10.
 Mabandla M, Kellaway L, St Clair Gibson A, Russell VA. Voluntary running provides neuroprotection in rats after 6-hydroxydopamine injection into the medial forebrain bundle. Metab Brain Dis. 2004 Jun;19(1-2):43-50.
 Rabelo PCR, Horta NAC, ... Soares DD. Intrinsic exercise capacity in rats influences dopamine neuroplasticity induced by physical training. J Appl Physiol (1985). 2017 Dec 1;123(6):1721-1729. doi: 10.1152/japplphysiol.00506.2017. Epub 2017 Sep 7.
 Gerecke KM, Jiao Y, Pani A, Pagala V, Smeyne RJ. Exercise protects against MPTP-induced neurotoxicity in mice. Brain Res. 2010 Jun 23;1341:72-83. doi: 10.1016/j.brainres.2010.01.053. Epub 2010 Jan 29.
 Wu SY, Wang TF, ... Kuo YM. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immun. 2011 Jan;25(1):135-46. doi: 10.1016/j.bbi.2010.09.006. Epub 2010 Sep 17.
 Robertson CL, Ishibashi K, ... London ED. Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment. Neuropsychopharmacology. 2016 May;41(6):1629-36. doi: 10.1038/npp.2015.331. Epub 2015 Oct 27.
 Mahapatra A. Overeating, obesity, and dopamine receptors. ACS Chem Neurosci. 2010 May 19;1(5):346-7. doi: 10.1021/cn100044y.
 Sevgi M, Rigoux L,... Tittgemeyer M. An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning. J Neurosci. 2015 Sep 9;35(36):12584-92. doi: 10.1523/JNEUROSCI.1589-15.2015.
 Rutledge RB, Smittenaar P, ... Dolan RJ. Risk Taking for Potential Reward Decreases across the Lifespan. Curr Biol. 2016 Jun 20;26(12):1634-1639. doi: 10.1016/j.cub.2016.05.017. Epub 2016 Jun 2.
 Norbury A, Manohar S, Rogers RD, Husain M. Dopamine modulates risk-taking as a function of baseline sensation-seeking trait. J Neurosci. 2013 Aug 7;33(32):12982-6. doi: 10.1523/JNEUROSCI.5587-12.2013.
 Norbury A, Husain M. Sensation-seeking: Dopaminergic modulation and risk for psychopathology. Behav Brain Res. 2015 Jul 15;288:79-93. doi: 10.1016/j.bbr.2015.04.015. Epub 2015 Apr 20.
 Kaasinen V, Aalto S, Någren K, Rinne JO. Expectation of caffeine induces dopaminergic responses in humans. Eur J Neurosci. 2004 Apr;19(8):2352-6.
 Volkow ND, Wang GJ, ... Tomasi D. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Transl Psychiatry. 2015 Apr 14;5:e549. doi: 10.1038/tp.2015.46.
 Manalo RVM, Medina PMB. Caffeine Protects Dopaminergic Neurons From Dopamine-Induced Neurodegeneration via Synergistic Adenosine-Dopamine D2-Like Receptor Interactions in Transgenic Caenorhabditis elegans. Front Neurosci. 2018 Mar 7;12:137. doi: 10.3389/fnins.2018.00137. eCollection 2018.
 Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992 May-Aug;17(2):139-70.
 Ferré S. Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders. Psychopharmacology (Berl). 2016 May;233(10):1963-79. doi: 10.1007/s00213-016-4212-2. Epub 2016 Jan 20.
 Kulkarni SK, Bhutani MK, Bishnoi M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl). 2008 Dec;201(3):435-42. doi: 10.1007/s00213-008-1300-y. Epub 2008 Sep 3.
 Kulkarni SK, Dhir A. An overview of curcumin in neurological disorders. Indian J Pharm Sci. 2010 Mar;72(2):149-54. doi: 10.4103/0250-474X.65012.
 Mythri RB, Bharath MM. Curcumin: a potential neuroprotective agent in Parkinson's disease. Curr Pharm Des. 2012;18(1):91-9.
 Du XX, Xu HM, Jiang H, Song N, Wang J, Xie JX. Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson's disease. Neurosci Bull. 2012 Jun;28(3):253-8. doi: 10.1007/s12264-012-1238-2.
 Rana DG, Galani VJ. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35(1):90-7. doi: 10.4103/0974-8520.141949.
 Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The Magic Velvet Bean of Mucuna pruriens. J Tradit Complement Med. 2012 Oct;2(4):331-9.
 Cilia R, Laguna J, ... Pezzoli G. Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study. Neurology. 2017 Aug 1;89(5):432-438. doi: 10.1212/WNL.0000000000004175. Epub 2017 Jul 5.
 Manyam BV, Dhanasekaran M, Hare TA. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Phytother Res. 2004 Sep;18(9):706-12.
 Stansley BJ, Yamamoto BK. L-Dopa and Brain Serotonin System Dysfunction. Toxics. 2015 Mar 5;3(1):75-88. doi: 10.3390/toxics3010075.
 Dodd FL, Kennedy DO, Riby LM, Haskell-Ramsay CF. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology (Berl). 2015 Jul;232(14):2563-76. doi: 10.1007/s00213-015-3895-0. Epub 2015 Mar 13.
 Yamada T, Terashima T, ... Yokogoshi H. Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission. Nutr Neurosci. 2005 Aug;8(4):219-26.
 Mirza B, Ikram H, Bilgrami S, Haleem DJ, Haleem MA. Neurochemical and behavioral effects of green tea (Camellia sinensis): a model study. Pak J Pharm Sci. 2013 May;26(3):511-6.
 Zhu G, Yang S, Xie Z, Wan X. Synaptic modification by L-theanine, a natural constituent in green tea, rescues the impairment of hippocampal long-term potentiation and memory in AD mice. Neuropharmacology. 2018 Aug;138:331-340. doi: 10.1016/j.neuropharm.2018.06.030. Epub 2018 Jun 23.
 Lardner AL. Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutr Neurosci. 2014 Jul;17(4):145-55. doi: 10.1179/1476830513Y.0000000079. Epub 2013 Nov 26.
 Yamada T, Terashima T, ... Yokogoshi H. Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino Acids. 2009 Jan;36(1):21-7. doi: 10.1007/s00726-007-0020-7. Epub 2008 Jan 15.
 Feduccia AA, Wang Y, ... Bartlett SE. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacol Biochem Behav. 2012 Aug;102(2):241-8. doi: 10.1016/j.pbb.2012.04.014. Epub 2012 May 9.
 Taylor L, Mumford P, ... Wilborn C. Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. J Int Soc Sports Nutr. 2016 Jan 13;13:2. doi: 10.1186/s12970-016-0113-3. eCollection 2016.
 Chen QG, Zeng YS, ... Hägg U. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine. 2009 Sep;16(9):830-8. doi: 10.1016/j.phymed.2009.03.011. Epub 2009 Apr 28.
 Seol GH, Shim HS, ... Min SS. Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats. J Ethnopharmacol. 2010 Jul 6;130(1):187-90. doi: 10.1016/j.jep.2010.04.035. Epub 2010 May 2.
 Mechan AO, Fowler A, ... Mohajeri MH. Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract. Br J Nutr. 2011 Apr;105(8):1150-63. doi: 10.1017/S0007114510004940. Epub 2010 Dec 21.
 Mechan AO, Fowler A, ... Mohajeri MH. Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract. Br J Nutr. 2011 Apr;105(8):1150-63. doi: 10.1017/S0007114510004940. Epub 2010 Dec 21.
 Zotti M1, Colaianna M, ... Trabace L. Carvacrol: from ancient flavoring to neuromodulatory agent. Molecules. 2013 May 24;18(6):6161-72. doi: 10.3390/molecules18066161.
 Kolling GJ, Panazzolo DM, ... Fischer V. Oregano Extract Added into the Diet of Dairy Heifers Changes Feeding Behavior and Concentrate Intake. ScientificWorldJournal. 2016;2016:8917817. doi: 10.1155/2016/8917817. Epub 2016 Dec 27.
 Noori Ahmad Abadi M, Mortazavi M, ... Ali-Akbari S. Effect of Hydroalcoholic Extract of Rosmarinus officinalis L. Leaf on Anxiety in Mice. J Evid Based Complementary Altern Med. 2016 Oct;21(4):NP85-90. doi: 10.1177/2156587216642101. Epub 2016 Apr 6.
 Kim SJ, Kim JS, ... Chun HS. Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells. Neuroreport. 2006 Nov 6;17(16):1729-33.
 Habtemariam S. The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease. Evid Based Complement Alternat Med. 2016;2016:2680409. doi: 10.1155/2016/2680409. Epub 2016 Jan 28.
 Bansal P, Banerjee S. Effect of Withinia Somnifera and Shilajit on Alcohol Addiction in Mice. Pharmacogn Mag. 2016 May;12(Suppl 2):S121-8. doi: 10.4103/0973-1296.182170. Epub 2016 May 11.
 Jun YL, Bae CH, Kim D, Koo S, Kim S. Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model. J Ginseng Res. 2015 Apr;39(2):148-54. doi: 10.1016/j.jgr.2014.10.003. Epub 2014 Nov 1.
 Halladay AK, Yu YL, Palmer J, Oh KW, Wagner GC. Acute and chronic effects of ginseng total saponin and amphetamine on fixed-interval performance in rats. Planta Med. 1999 Mar;65(2):162-4.
 Oh KW, Kim HS, Wagner GC. Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine. Planta Med. 1997 Feb;63(1):80-1.
 Nah SY, Bhatia KS, Lyles J, Ellinwood EH, Lee TH. Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens. Brain Res. 2009 Jan 12;1248:184-90. doi: 10.1016/j.brainres.2008.10.064. Epub 2008 Nov 8.
 Shim IS, Won JS, ... Suh HW. Modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat. ] J Ethnopharmacol. 2000 May;70(2):161-9.
 Kim SE, Shim I, Chung JK, Lee MC. Effect of ginseng saponins on enhanced dopaminergic transmission and locomotor hyperactivity induced by nicotine. Neuropsychopharmacology. 2006 Aug;31(8):1714-21. Epub 2005 Oct 26.
 Sershen H, Harsing LG Jr ... Lajtha A. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain. J Neurosci Res. 1991 Nov;30(3):555-9.
 Singh S, Mishra A, ... Shukla S. Acetyl-L-Carnitine via Upegulating Dopamine D1 Receptor and Attenuating Microglial Activation Prevents Neuronal Loss and Improves Memory Functions in Parkinsonian Rats. Mol Neurobiol. 2018 Jan;55(1):583-602. doi: 10.1007/s12035-016-0293-5. Epub 2016 Dec 14.
 Tolu P, Masi F, ... Gambarana C. Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. Neuropsychopharmacology. 2002 Sep;27(3):410-20.
 Robinson BL, Dumas M,... Kanungo J. Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish. Neurotoxicol Teratol. 2016 Mar-Apr;54:52-60. doi: 10.1016/j.ntt.2016.02.004. Epub 2016 Feb 16.
 Smeland OB, Meisingset TW, Borges K, Sonnewald U. Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochem Int. 2012 Jul;61(1):100-7. doi: 10.1016/j.neuint.2012.04.008. Epub 2012 Apr 23.
 Virmani A, Gaetani F, Imam S, Binienda Z, Ali S. Possible mechanism for the neuroprotective effects of L-carnitine on methamphetamine-evoked neurotoxicity. Ann N Y Acad Sci. 2003 May;993:197-207; discussion 287-8.
 Afshin-Majd S, Bashiri K, ... Roghani M. Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. Biomed Pharmacother. 2017 May;89:1-9. doi: 10.1016/j.biopha.2017.02.007. Epub 2017 Feb 12.
 Chiechio S, Canonico PL, Grilli M. l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug. Int J Mol Sci. 2017 Dec 21;19(1). pii: E11. doi: 10.3390/ijms19010011.
 Masi F, Leggio B, ... Gambarana C. Effects of long-term acetyl-L-carnitine administration in rats--II: Protection against the disrupting effect of stress on the acquisition of appetitive behavior. Neuropsychopharmacology. 2003 Apr;28(4):683-93. Epub 2002 Oct 1.
 Evcimen H, Mania I, Mathews M, Basil B. Psychosis Precipitated by Acetyl-l-Carnitine in a Patient With Bipolar Disorder. Prim Care Companion J Clin Psychiatry. 2007;9(1):71-2.
 Vance KM, Ribnicky DM, Hermann GE, Rogers RC. St. John's Wort enhances the synaptic activity of the nucleus of the solitary tract. Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S37-42. doi: 10.1016/j.nut.2014.02.008. Epub 2014 Feb 28.
 Butterweck V, Böckers T, ... Winterhoff H. Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res. 2002 Mar 15;930(1-2):21-9.
 Ben-Eliezer D, Yechiam E. Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis. Sci Rep. 2016 Oct 20;6:35700. doi: 10.1038/srep35700.
 Butterweck V, Böckers T, Korte B, Wittkowski W, Winterhoff H. Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res. 2002 Mar 15;930(1-2):21-9.
 Nathan PJ. Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. J Psychopharmacol. 2001 Mar;15(1):47-54.
 Yoshitake T, Iizuka R,... Kehr J. Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol. 2004 Jun;142(3):414-8. Epub 2004 May 17.
 Sarris J, Price LH, ... Mischoulon D. Is S-Adenosyl Methionine (SAMe) for Depression Only Effective in Males? A Re-Analysis of Data from a Randomized Clinical Trial. Pharmacopsychiatry. 2015 Jul;48(4-5):141-4. doi: 10.1055/s-0035-1549928. Epub 2015 May 26.
 Lee ES, Chen H, ... Charlton CG. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neurosci Res. 2004 Mar;48(3):335-44.
 Fava M, Rosenbaum JF, ... Pill L. Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant. J Psychiatr Res. 1990;24(2):177-84.
 Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther. 2007 Oct;116(1):107-24. Epub 2007 Jun 16.
 Marx CE, Keefe RS, ... Shampine LJ. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology. 2009 Jul;34(8):1885-903. doi: 10.1038/npp.2009.26. Epub 2009 Apr 1.
 Turkmen S, Backstrom T, ... Johansson IM. Tolerance to allopregnanolone with focus on the GABA-A receptor. Br J Pharmacol. 2011 Jan;162(2):311-27. doi: 10.1111/j.1476-5381.2010.01059.x.
 Sripada RK, Marx CE, ... Liberzon I. Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits. Biol Psychiatry. 2013 Jun 1;73(11):1045-53. doi: 10.1016/j.biopsych.2012.12.008. Epub 2013 Jan 21.
 Veiga S, Garcia-Segura LM, Azcoitia I. Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase. J Neurobiol. 2003 Sep 15;56(4):398-406.
 Steiger A, Trachsel L, ... Holsboer F. Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Res. 1993 Jul 2;615(2):267-74.
 Muneoka KT, Takigawa M. A neuroactive steroid, pregnenolone, alters the striatal dopaminergic tone before and after puberty. Neuroendocrinology. 2002 May;75(5):288-95.
 Barrot M1, Vallée M, ...Piazza PV. The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens. Eur J Neurosci. 1999 Oct;11(10):3757-60.
 Wong P, Sze Y, Chang CC, Lee J, Zhang X. Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway. Transl Psychiatry. 2015 Mar 17;5:e528. doi: 10.1038/tp.2015.21.
 Labrie F. DHEA, important source of sex steroids in men and even more in women. Prog Brain Res. 2010;182:97-148. doi: 10.1016/S0079-6123(10)82004-7.
 Catalina F, Milewich L, Frawley W, Kumar V, Bennett M. Decrease of core body temperature in mice by dehydroepiandrosterone. Exp Biol Med (Maywood). 2002 Jun;227(6):382-8.
 D'Astous M, Morissette M, ... Di Paolo T. Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice. Synapse. 2003 Jan;47(1):10-4.
 Wang L, Pooler AM, Albrecht MA, Wurtman RJ. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-45.
 Yamamoto T, Moriwaki Y, ... Hada T. Effect of beer on the plasma concentrations of uridine and purine bases. Metabolism: Clinical and Experimental 2002, 51 (10): 1317–23.
 Carver JD. Advances in nutritional modifications of infant formulas. The American Journal of Clinical Nutrition 2003 77 (6): 1550S–1554S.
 Wang L, Pooler AM, Albrecht MA, Wurtman RJ. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-45.
 Agarwal N, Sung YH, ... Renshaw PF. Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T. Bipolar Disord. 2010 Dec;12(8):825-33. doi: 10.1111/j.1399-5618.2010.00884.x.
 Yeh KY, Wu CH, Tai MY, Tsai YF. Ginkgo biloba extract enhances noncontact erection in rats: the role of dopamine in the paraventricular nucleus and the mesolimbic system. Neuroscience. 2011 Aug 25;189:199-206. doi: 10.1016/j.neuroscience.2011.05.025. Epub 2011 May 30.
 Yoshitake T, Yoshitake S, Kehr J. The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol. 2010 Feb 1;159(3):659-68. doi: 10.1111/j.1476-5381.2009.00580.x. Epub 2010 Jan 25.
 Kehr J, Yoshitake S, Ijiri S, Koch E, Nöldner M, Yoshitake T. Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®. Int Psychogeriatr. 2012 Aug;24 Suppl 1:S25-34. doi: 10.1017/S1041610212000567.
 Beck SM, Ruge H, ... Goschke T. Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment - a randomized double-blind placebo-controlled trial. Hum Psychopharmacol. 2016 May;31(3):227-42. doi: 10.1002/hup.2534.
 Fehske CJ, Leuner K, Müller WE. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacol Res. 2009 Jul;60(1):68-73. doi: 10.1016/j.phrs.2009.02.012. Epub 2009 Mar 21.
 Mix JA, Crews WD Jr. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Hum Psychopharmacol. 2002 Aug;17(6):267-77.
 Cieza A, Maier P, Pöppel E. Effects of Ginkgo biloba on mental functioning in healthy volunteers. Arch Med Res. 2003 Sep-Oct;34(5):373-81.
 .Johansson MH, Westlind-Danielsson A. Forskolin-induced up-regulation and functional supersensitivity of dopamine D2long receptors expressed by Ltk- cells. Eur J Pharmacol. 1994 Oct 14;269(2):149-55
 Wanderoy MH, Westlind-Danielsson A. Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors. Cell Mol Neurobiol. 1997 Oct;17(5):547-55.
 Wanderoy MH, Westlind-Danielsson A, Ahlenius S. Dopamine D2 receptor upregulation in rat neostriatum following in vivo infusion of forskolin. Neuroreport. 1997 Sep 8;8(13):2971-6.
 Katz IR, Smith D, Makman MH. Forskolin stimulates the conversion of tyrosine to dopamine in catecholaminergic neural tissue. Brain Res. 1983 Mar 28;264(1):173-7.
 Alirezaei M. Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats. Iran J Basic Med Sci. 2015 Oct;18(10):950-7.
 Di Pierro F, Orsi R, Settembre R. Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression. J Multidiscip Healthc. 2015 Jan 16;8:39-45. doi: 10.2147/JMDH.S77766. eCollection 2015.
 Di Chiara G. Alcohol and dopamine. Alcohol Health Res World. 1997;21(2):108-14.
 Ma H, Zhu G. The dopamine system and alcohol dependence. Shanghai Arch Psychiatry. 2014 Apr;26(2):61-8. doi: 10.3969/j.issn.1002-0829.2014.02.002.
 Melis M, Diana M, Enrico P, Marinelli M, Brodie MS. Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress. Alcohol. 2009 Nov;43(7):531-9. doi: 10.1016/j.alcohol.2009.05.004.
 Trantham-Davidson H, Chandler LJ. Alcohol-induced alterations in dopamine modulation of prefrontal activity. Alcohol. 2015 Dec;49(8):773-9. doi: 10.1016/j.alcohol.2015.09.001. Epub 2015 Oct 23.
 Ding ZM, Ingraham CM, Rodd ZA, McBride WJ. Alcohol drinking increases the dopamine-stimulating effects of ethanol and reduces D2 auto-receptor and group II metabotropic glutamate receptor function within the posterior ventral tegmental area of alcohol preferring (P) rats. Neuropharmacology. 2016 Oct;109:41-48. doi: 10.1016/j.neuropharm.2016.05.023. Epub 2016 May 31.
 Trantham-Davidson H, Burnett EJ, ... Chandler LJ. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014 Mar 5;34(10):3706-18. doi: 10.1523/JNEUROSCI.0623-13.2014.
 Bustamante D, Quintanilla ME, ... Herrera-Marschitz M. Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats. Eur J Pharmacol. 2008 Sep 4;591(1-3):153-8. doi: 10.1016/j.ejphar.2008.06.069. Epub 2008 Jun 24.
 Andres RH1, Huber AW, ... Widmer HR. Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue. Neuroscience. 2005;133(3):701-13.
 Cunha MP, Machado DG, ... Rodrigues AL. Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26(11):1489-501. doi: 10.1177/0269881112447989. Epub 2012 Jun 6.
 Riesberg LA, Weed SA, McDonald TL, Eckerson JM, Drescher KM. Beyond muscles: The untapped potential of creatine. Int Immunopharmacol. 2016 Aug;37:31-42. doi: 10.1016/j.intimp.2015.12.034. Epub 2016 Jan 8.
 Andres RH, Ducray AD, Pérez... Widmer HR. Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system. Cell Transplant. 2005;14(8):537-50.
 Beal MF. Neuroprotective effects of creatine. Amino Acids. 2011 May;40(5):1305-13. doi: 10.1007/s00726-011-0851-0. Epub 2011 Mar 30.
 Cunha MP, Martín-de-Saavedra MD, ... López MG. Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model. ASN Neuro. 2014 Nov 24;6(6). pii: 1759091414554945. doi: 10.1177/1759091414554945. Print 2014.
 Greenway SE, Pack AT, Greenway FL. Treatment of depression with cyproheptadine. Pharmacotherapy. 1995 May-Jun;15(3):357-60.
 Dabaghzadeh F1, Ghaeli P, ... Khazaeipour Z. Cyproheptadine for prevention of neuropsychiatric adverse effects of efavirenz: a randomized clinical trial. AIDS Patient Care STDS. 2013 Mar;27(3):146-54. doi: 10.1089/apc.2012.0410. Epub 2013 Feb 26.
 Konstandi M, Kolijianni A, Sfikakis AD. Effect of cyproheptadine treatment on conditioned avoidance response in female rats. Gen Pharmacol. 1996 Dec;27(8):1401-3.
 Plonk J, Feldman J. Modification of adrenal function by the anti-serotonin agent cyproheptadine. J Clin Endocrinol Metab. 1976 Feb;42(2):291-5.
 Delitala G, Masala A, Alagna S, Devilla L. Effect of cyproheptadine on the spontaneous diurnal variations of plasma ACTH-cortisol and ACTH-GH secretion induced by l-dopa. Biomedicine. 1975 Dec 20;23(10):406-9.
 Krieger DT, Amorosa L, Linick F. Cyproheptadine-induced remission of Cushing's disease. N Engl J Med. 1975 Oct 30;293(18):893-6.
 Mogilnicka E, Scheel-Krüger J, Klimek V, Golembiowska-Nikitin K. The influence of antiserotonergic agents on the action of dopaminergic drugs. Pol J Pharmacol Pharm. 1977 Jan-Feb;29(1):31-8.
 Opacka-Juffry J, Ashworth S, Ahier RG, Hume SP. Modulatory effects of L-DOPA on D2 dopamine receptors in rat striatum, measured using in vivo microdialysis and PET. J Neural Transm (Vienna). 1998;105(4-5):349-64.
 Murata M, Kanazawa I. Repeated L-dopa administration reduces the ability of dopamine storage and abolishes the supersensitivity of dopamine receptors in the striatum of intact rat. Neurosci Res. 1993 Jan;16(1):15-23.
 Snyder GL, Zigmond MJ. The effects of L-dopa on in vitro dopamine release from striatum. Brain Res. 1990 Feb 5;508(2):181-7.
 Schneider MB, Murrin LC, Pfeiffer RF, Deupree JD. Dopamine receptors: effects of chronic L-dopa and bromocriptine treatment in an animal model of Parkinson's disease. Clin Neuropharmacol. 1984;7(3):247-57.
 Guatteo E, Yee A, ... Lipski J. Dual effects of L-DOPA on nigral dopaminergic neurons. Exp Neurol. 2013 Sep;247:582-94. doi: 10.1016/j.expneurol.2013.02.009. Epub 2013 Feb 26.
 Borah A, Mohanakumar KP. Long-term L-DOPA treatment causes indiscriminate increase in dopamine levels at the cost of serotonin synthesis in discrete brain regions of rats. Cell Mol Neurobiol. 2007 Dec;27(8):985-96. Epub 2007 Oct 13.
 García NH, Berndt TJ, Tyce GM, Knox FG. Chronic oral L-DOPA increases dopamine and decreases serotonin excretions. Am J Physiol. 1999 Nov;277(5):R1476-80. doi: 10.1152/ajpregu.1999.277.5.R1476.
 Siciliano CA, Fordahl SC, Jones SR. Cocaine Self-Administration Produces Long-Lasting Alterations in Dopamine Transporter Responses to Cocaine. J Neurosci. 2016 Jul 27;36(30):7807-16. doi: 10.1523/JNEUROSCI.4652-15.2016.
 Verma V. Classic Studies on the Interaction of Cocaine and the Dopamine Transporter. Clin Psychopharmacol Neurosci. 2015 Dec 31;13(3):227-38. doi: 10.9758/cpn.2015.13.3.227
 Kiyatkin EA. Dopamine mechanisms of cocaine addiction. Int J Neurosci. 1994 Sep;78(1-2):75-101.
 Venton BJ, Seipel AT, ... Wightman RM. Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci. 2006 Mar 22;26(12):3206-9.
 Hummel M, Unterwald EM. D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action. J Cell Physiol. 2002 Apr;191(1):17-27.
 Volkow ND, Fowler JS, Wang GJ. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol. 1999 Dec;13(4):337-45.
 Wang GJ, Volkow ND, ... Swanson JM. Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. PLoS One. 2013 May 15;8(5):e63023. doi: 10.1371/journal.pone.0063023. Print 2013.
 Sadasivan S, Pond BB, Pani AK, Qu C, Jiao Y, Smeyne RJ. Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice. PLoS One. 2012;7(3):e33693. doi: 10.1371/journal.pone.0033693. Epub 2012 Mar 21.
 Engert V, Pruessner JC. Dopaminergic and noradrenergic contributions to functionality in ADHD: the role of methylphenidate. Curr Neuropharmacol. 2008 Dec;6(4):322-8. doi: 10.2174/157015908787386069.
 Calipari ES, Ferris MJ, ... Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013;4:2720. doi: 10.1038/ncomms3720.
 Kodama T, Kojima T, ... Watanabe M. Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey. J Neurosci. 2017 Mar 1;37(9):2387-2394. doi: 10.1523/JNEUROSCI.2155-16.2017. Epub 2017 Feb 2.
 Morton WA, Stockton GG. Methylphenidate Abuse and Psychiatric Side Effects. Prim Care Companion J Clin Psychiatry. 2000 Oct;2(5):159-164.
 Yanofski J. The Dopamine Dilemma-Part II: Could Stimulants Cause Tolerance, Dependence, and Paradoxical Decompensation? Innov Clin Neurosci. 2011 Jan;8(1):47-53.
 Joyce BM, Glaser PE, Gerhardt GA. Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. Psychopharmacology (Berl). 2007 Apr;191(3):669-77. Epub 2006 Oct 10.
 Berman SM, Kuczenski R, McCracken JT, London ED. Potential adverse effects of amphetamine treatment on brain and behavior: a review. Mol Psychiatry. 2009 Feb;14(2):123-42. doi: 10.1038/mp.2008.90. Epub 2008 Aug 12.
 Lakhan SE, Kirchgessner A. Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain Behav. 2012 Sep;2(5):661-77. doi: 10.1002/brb3.78. Epub 2012 Jul 23.
 Novak G, Seeman P, Le Foll B. Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity. Int J Neurosci. 2010 Nov;120(11):691-7. doi: 10.3109/00207454.2010.513462.
 Herman AI, DeVito EE, Jensen KP, Sofuoglu M. Pharmacogenetics of nicotine addiction: role of dopamine. Pharmacogenomics. 2014 Feb;15(2):221-34. doi: 10.2217/pgs.13.246.
 Pidoplichko VI, DeBiasi M, Williams JT, Dani JA. Nicotine activates and desensitizes midbrain dopamine neurons. Nature. 1997 Nov 27;390(6658):401-4.
 Perez XA, Ly J, McIntosh JM, Quik M. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. J Pharmacol Exp Ther. 2012 Aug;342(2):335-44. doi: 10.1124/jpet.112.194084. Epub 2012 May 4.
 Joshi YB, Friend SF, Jimenez B, Steiger LR. Dissociative Intoxication and Prolonged Withdrawal Associated With Phenibut: A Case Report. J Clin Psychopharmacol. 2017 Aug;37(4):478-480. doi: 10.1097/JCP.0000000000000731.
 Lapin I. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001 Winter;7(4):471-81.
 Loland CJ, Mereu M, ... Newman AH. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biol Psychiatry. 2012 Sep 1;72(5):405-13. doi: 10.1016/j.biopsych.2012.03.022. Epub 2012 Apr 25.
 Andersen ML, Kessler E, ... Howell LL. Dopamine transporter-related effects of modafinil in rhesus monkeys. Psychopharmacology (Berl). 2010 Jun;210(3):439-48. doi: 10.1007/s00213-010-1839-2. Epub 2010 Apr 13.
 Mereu M, Bonci A, Newman AH, Tanda G. The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders. Psychopharmacology (Berl). 2013 Oct;229(3):415-34. doi: 10.1007/s00213-013-3232-4. Epub 2013 Aug 10.
 Young JW, Geyer MA. Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors? Biol Psychiatry. 2010 Apr 15;67(8):784-7. doi: 10.1016/j.biopsych.2009.12.015. Epub 2010 Feb 4.
 Volkow ND, Fowler JS,... Apelskog-Torres K. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA. 2009 Mar 18;301(11):1148-54. doi: 10.1001/jama.2009.351.
 Moe RO, Nordgreen J, ... Bakken M. Effects of haloperidol, a dopamine D2-like receptor antagonist, on reward-related behaviors in laying hens. Physiol Behav. 2011 Mar 1;102(3-4):400-5. doi: 10.1016/j.physbeh.2010.12.008. Epub 2010 Dec 14.
 Fox CA, Mansour A, Watson SJ Jr. The effects of haloperidol on dopamine receptor gene expression. Exp Neurol. 1994 Dec;130(2):288-303.
 Lidsky TI, Banerjee SP. Acute administration of haloperidol enhances dopaminergic transmission. J Pharmacol Exp Ther. 1993 Jun;265(3):1193-8.
 Zanatta G, Nunes G, ... Gottfried C. Antipsychotic haloperidol binding to the human dopamine D3 receptor: beyond docking through QM/MM refinement toward the design of improved schizophrenia medicines. ACS Chem Neurosci. 2014 Oct 15;5(10):1041-54. doi: 10.1021/cn500111e. Epub 2014 Sep 18.
 Saeedi H, Remington G, Christensen BK. Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood. Schizophr Res. 2006 Jul;85(1-3):222-31. Epub 2006 May 6.
 Carlson SW, Dixon CE. Lithium Improves Dopamine Neurotransmission and Increases Dopaminergic Protein Abundance in the Striatum after Traumatic Brain Injury. J Neurotrauma. 2018 Dec 1;35(23):2827-2836. doi: 10.1089/neu.2017.5509. Epub 2018 Aug 13.
 Staunton DA, Magistretti PJ, Shoemaker WJ, Deyo SN, Bloom FE. Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. II. No effect on denervation or neuroleptic-induced supersensitivity. Brain Res. 1982 Jan 28;232(2):401-12.
 Alevizos B, Alevizos E, Leonardou A, Zervas I. Low dosage lithium augmentation in venlafaxine resistant depression: an open-label study. Psychiatriki. 2012 Apr-Jun;23(2):143-8.
 Blier P, de Montigny C, Tardif D. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse. 1987;1(3):225-32.
 Kameda K, Miura J, ... Koyama T. Effects of lithium on dopamine D2 receptor expression in the rat brain striatum. J Neural Transm (Vienna). 2001;108(3):321-34.
 Stamford JA, Kruk ZL, Millar J. Striatal dopamine terminals release serotonin after 5-HTP pretreatment: in vivo voltammetric data. Brain Res. 1990 May 7;515(1-2):173-80.
 Trachte GJ, Uncini T, Hinz M. Both stimulatory and inhibitory effects of dietary 5-hydroxytryptophan and tyrosine are found on urinary excretion of serotonin and dopamine in a large human population. Neuropsychiatr Dis Treat. 2009;5:227-35. Epub 2009 May 20.
 Molina-Holgado E, Dewar KM, Descarries L, Reader TA. Altered dopamine and serotonin metabolism in the dopamine-denervated and serotonin-hyperinnervated neostriatum of adult rat after neonatal 6-hydroxydopamine. J Pharmacol Exp Ther. 1994 Aug;270(2):713-21.
 Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience. 2005;134(3):737-44.
 Murray S, Tulloch A, Criscitelli K, Avena NM. Recent studies of the effects of sugars on brain systems involved in energy balance and reward: Relevance to low calorie sweeteners. Physiol Behav. 2016 Oct 1;164(Pt B):504-508. doi: 10.1016/j.physbeh.2016.04.004. Epub 2016 Apr 9.
 Miranda MI, Rangel-Hernández JA, ... Núñez-Jaramillo L. The role of dopamine D2 receptors in the nucleus accumbens during taste-aversive learning and memory extinction after long-term sugar consumption. Neuroscience. 2017 Sep 17;359:142-150. doi: 10.1016/j.neuroscience.2017.07.009. Epub 2017 Jul 14.
 Naneix F, Darlot F, ... Cador M. Protracted motivational dopamine-related deficits following adolescence sugar overconsumption. Neuropharmacology. 2018 Feb;129:16-25. doi: 10.1016/j.neuropharm.2017.11.021. Epub 2017 Nov 13.
 Overstreet DH, Crocker AD, ... Crocker JM. Alterations in the dopaminergic system and behaviour in rats reared on iodine-deficient diets. Pharmacol Biochem Behav. 1984 Oct;21(4):561-5.
 Crocker AD, Overstreet DH, Crocker JM. Hypothyroidism leads to increased dopamine receptor sensitivity and concentration. Pharmacol Biochem Behav. 1986 Jun;24(6):1593-7.
 Eskildsen PC, Kirkegaard CB. The influence of thyroid disorders on the dopaminergic regulation of prolactin, thyrotropin and growth hormone. J Endocrinol Invest. 1985 Oct;8(5):427-31.
 Feek CM, Sawers JS, ... Toft AD. Influence of thyroid status on dopaminergic inhibition of thyrotropin and prolactin secretion: evidence for an additional feedback mechanism in the control of thyroid hormone secretion. J Clin Endocrinol Metab. 1980 Sep;51(3):585-9.
 Oh-Nishi A , Saji M, Furudate SI, Suzuki N. Dopamine D(2)-like receptor function is converted from excitatory to inhibitory by thyroxine in the developmental hippocampus. J Neuroendocrinol. 2005 Dec;17(12):836-45.
 Dieguez C, Peters JR, ... Scanlon MF. Thyroid function in patients with hyperprolactinaemia: relationship to dopaminergic inhibition of TSH release. Clin Endocrinol (Oxf). 1986 Oct;25(4):435-40.
 Sasaki A, Hanew K, Sato S, Yoshinaga K. Evidence for endogenous dopaminergic regulation of thyrotropin (TSH) secretion in man. Tohoku J Exp Med. 1983 Jan;139(1):1-7.
 Chung J, Chang S, Kim Y, Shin H. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neurosci Lett. 2000 Jun 9;286(3):183-6.
 Turner TY, Soliman MR. Effects of zinc on spatial reference memory and brain dopamine (D1) receptor binding kinetics in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Oct;24(7):1203-17.
 Schetz JA, Chu A, Sibley DR. Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms. J Pharmacol Exp Ther. 1999 May;289(2):956-64.
 Doboszewska U, Wlaź P, ... Młyniec K. Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity. Neural Plast. 2017;2017:3682752. doi: 10.1155/2017/3682752. Epub 2017 Feb 19.
 Youdim MB, Ben-Shachar D, Ashkenazi R, Yehuda S. Brain iron and dopamine receptor function. Adv Biochem Psychopharmacol. 1983;37:309-21.
 Pino JMV, da Luz MHM, ... Lee KS. Iron-Restricted Diet Affects Brain Ferritin Levels, Dopamine Metabolism and Cellular Prion Protein in a Region-Specific Manner. Front Mol Neurosci. 2017 May 17;10:145. doi: 10.3389/fnmol.2017.00145. eCollection 2017.
 Jellen LC, Lu L, ... Jones BC. Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience. 2013 Nov 12;252:13-23. doi: 10.1016/j.neuroscience.2013.07.058. Epub 2013 Aug 1.
 Yien YY, Paw BH. A role for iron deficiency in dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3417-8. doi: 10.1073/pnas.1601976113. Epub 2016 Mar 16.
 Matak P, Matak A, ... Andrews NC. Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3428-35. doi: 10.1073/pnas.1519473113. Epub 2016 Feb 29.
 Symes AL, Sourkes TL ... Birnbaum H. Decreased monoamine oxidase activity in liver of iron-deficient rats. Can J Biochem. 1969 Nov;47(11):999-1002.
 Youdim MB, Green AR. Iron deficiency and neurotransmitter synthesis and function. Proc Nutr Soc. 1978 Sep;37(2):173-9.
 Hare DJ, Double KL. Iron and dopamine: a toxic couple. Brain. 2016 Apr;139(Pt 4):1026-35.
 Li Y, Kim J, ... Wessling-Resnick M. Severe postnatal iron deficiency alters emotional behavior and dopamine levels in the prefrontal cortex of young male rats. Nutr. 2011 Dec;141(12):2133-8. doi: 10.3945/jn.111.145946. Epub 2011 Oct 19.
 Lozoff B, Corapci F, ... Black M. Preschool-aged children with iron deficiency anemia show altered affect and behavior. J Nutr. 2007 Mar;137(3):683-9.
 Yehuda S, Youdim MB. Brain iron: a lesson from animal models. Am J Clin Nutr. 1989 Sep;50(3 Suppl):618-25; discussion 625-9. doi: 10.1093/ajcn/50.3.618.
 Rasekh HR1, Davis MD, ... Soliman KF. The effect of selenium on the central dopaminergic system: a microdialysis study. Life Sci. 1997;61(11):1029-35.
 Castaño A, Ayala A, ..., Machado A. Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat. Neurochem Int. 1997 Jun;30(6):549-55.
 Solovyev ND. Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling. J Inorg Biochem. 2015 Dec;153:1-12. doi: 10.1016/j.jinorgbio.2015.09.003. Epub 2015 Sep 15.
 Naderi M, Ferrari MCO, ... Niyogi S. Maternal Exposure to Dietary Selenium Causes Dopaminergic Hyperfunction and Cognitive Impairment in Zebrafish Offspring. Environ Sci Technol. 2018 Nov 20;52(22):13574-13583. doi: 10.1021/acs.est.8b04768. Epub 2018 Oct 30.
 Khan HA. Selenium partially reverses the depletion of striatal dopamine and its metabolites in MPTP-treated C57BL mice. Neurochem Int. 2010 Nov;57(5):489-91. doi: 10.1016/j.neuint.2010.06.020. Epub 2010 Jul 7.
 Watanabe M, George SR, Seeman P. Regulation of anterior pituitary D2 dopamine receptors by magnesium and sodium ions. J Neurochem. 1985 Dec;45(6):1842-9.
 Vink R. Magnesium in the Central Nervous System. Magnesium in Parkinson’s disease: an update in clinical and basic aspects. University of Adelaide Press; 2011.
 Mena MA, Garcia de Yébenes MJ, ... Garcia de Yébenes J. Effects of calcium antagonists on the dopamine system. Clin Neuropharmacol. 1995 Oct;18(5):410-26.
 Leviel V, Valérie O, Guibert B. The Role of Calcium Ions in Dopamine Synthesis and Dopamine Release. The Basal Ganglia IV: 403-409
 Zhou WL, Antic SD. Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons. J Physiol. 2012 Aug 15;590(16):3891-911. doi: 10.1113/jphysiol.2011.227157. Epub 2012 May 28.
 Ericson M, Molander A, Stomberg R, Söderpalm B. Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine. Eur J Neurosci. 2006 Jun;23(12):3225-9.
 Chen VC, Chiu CC, ... Tzang BS. Effects of taurine on striatal dopamine transporter expression and dopamine uptake in SHR rats. Behav Brain Res. 2018 Aug 1;348:219-226. doi: 10.1016/j.bbr.2018.04.031. Epub 2018 Apr 22.
 Guilarte TR. Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum. Neurochem Res. 1989 Jun;14(6):571-8.
 Weir MR, Keniston RC, Enriquez JI Sr, McNamee GA. Depression of vitamin B6 levels due to dopamine. Vet Hum Toxicol. 1991 Apr;33(2):118-21.
 Stahl SM. L-methylfolate: a vitamin for your monoamines. J Clin Psychiatry. 2008 Sep;69(9):1352-3.
 Duan W, Ladenheim B, ... Mattson MP. Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem. 2002 Jan;80(1):101-10.
 Miller AL. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev. 2008 Sep;13(3):216-26.
 Deana R, Vincenti E, Deana AD. Levels of neurotransmitters in brain of vitamin B12 deficient rats. Int J Vitam Nutr Res. 1977;47(2):119-22.
 de Lau LM, Koudstaal PJ, ... Breteler MM. Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. Neurology. 2006 Jul 25;67(2):315-8.
 Lövblad K, Ramelli G, Remonda L, ... Schroth G. Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings. Pediatr Radiol. 1997 Feb;27(2):155-8.
 Giménez R, Raïch J, Aguilar J. Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice. Br J Pharmacol. 1991 Nov;104(3):575-8.
 Shibuya M, Kageyama N, ... Fujiwara M. Effects of CDP-choline on striatal dopamine level and behavior in rats. Jpn J Pharmacol. 1981 Feb;31(1):47-52.
 Secades JJ, Frontera G. CDP-choline: pharmacological and clinical review. Methods Find Exp Clin Pharmacol. 1995 Oct;17 Suppl B:1-54.
 Hryhorczuk C, Florea M, ... Fulton S. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Neuropsychopharmacology. 2016 Feb;41(3):811-21. doi: 10.1038/npp.2015.207. Epub 2015 Jul 14.
 Dumas JA, Bunn JY,... Kien CL. Dietary saturated fat and monounsaturated fat have reversible effects on brain function and the secretion of pro-inflammatory cytokines in young women. Metabolism. 2016 Oct;65(10):1582-8. doi: 10.1016/j.metabol.2016.08.003. Epub 2016 Aug 9.
 Brenneman DE, Rutledge CO. Alteration of catecholamine uptake in cerebral cortex from rats fed a saturated fat diet. Brain Res. 1979 Dec 28;179(2):295-304.
 Goldberg LI. The role of dopamine receptors in the treatment of congestive heart failure. J Cardiovasc Pharmacol. 1989;14 Suppl 5:S19-27.
 Olsen NV. Effects of dopamine on renal haemodynamics tubular function and sodium excretion in normal humans. Dan Med Bull. 1998 Jun;45(3):282-97.
 Harris RC, Zhang MZ. Dopamine, the kidney, and hypertension. Curr Hypertens Rep. 2012 Apr;14(2):138-43. doi: 10.1007/s11906-012-0253-z.
 Choi MR, Kouyoumdzian NM, ... Fernández BE. Renal dopaminergic system: Pathophysiological implications and clinical perspectives. World J Nephrol. 2015 May 6;4(2):196-212. doi: 10.5527/wjn.v4.i2.196.
 Shnitko TA, Taylor SC,... Robinson DL. Acute phenylalanine/tyrosine depletion of phasic dopamine in the rat brain. Psychopharmacology (Berl). 2016 Jun;233(11):2045-2054. doi: 10.1007/s00213-016-4259-0. Epub 2016 Mar 5.
 Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007 Jun;137(6 Suppl 1):1539S-1547S; discussion 1548S. doi: 10.1093/jn/137.6.1539S.
 Montioli R, Cellini B, Dindo M, Oppici E, Voltattorni CB. Interaction of human Dopa decarboxylase with L-Dopa: spectroscopic and kinetic studies as a function of pH. Biomed Res Int. 2013;2013:161456. doi: 10.1155/2013/161456. Epub 2013 May 26.
 Treseder SA, Jackson M, Jenner P. The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates. Br J Pharmacol. 2000 Apr;129(7):1355-64.
 Olson CA, Thornton JA, Adam GE, Lieberman HR. Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood. J Clin Psychopharmacol. 2010 Oct;30(5):573-8. doi: 10.1097/JCP.0b013e3181ee0f79.
 Alexander SP. Flavonoids as antagonists at A1 adenosine receptors. Phytother Res. 2006 Nov;20(11):1009-12.
 Sommer T, Hübner H, ... Clark T. Identification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database. Sci Rep. 2017 Mar 10;7:44201. doi: 10.1038/srep44201.
 Field T, Hernandez-Reif M, ... Kuhn C. Cortisol decreases and serotonin and dopamine increase following massage therapy. Int J Neurosci. 2005 Oct;115(10):1397-413.
 Landau AM, Chakravarty MM, Clark CM, Zis AP, Doudet DJ. Electroconvulsive therapy alters dopamine signaling in the striatum of non-human primates. Neuropsychopharmacology. 2011 Jan;36(2):511-8. doi: 10.1038/npp.2010.182. Epub 2010 Oct 13.
 Baldinger P, Lotan A, Frey R, Kasper S, Lerer B, Lanzenberger R. Neurotransmitters and electroconvulsive therapy. J ECT. 2014 Jun;30(2):116-21. doi: 10.1097/YCT.0000000000000138.
 Singh A, Kar SK. How Electroconvulsive Therapy Works?: Understanding the Neurobiological Mechanisms. Clin Psychopharmacol Neurosci. 2017 Aug 31;15(3):210-221. doi: 10.9758/cpn.2017.15.3.210.
 Arnsten AF. Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci. 2009 Jun;10(6):410-22. doi: 10.1038/nrn2648.
 Isovich E, Mijnster MJ, Flügge G, Fuchs E. Chronic psychosocial stress reduces the density of dopamine transporters. Eur J Neurosci. 2000 Mar;12(3):1071-8.
 Yadid G, Pacak K, ... Goldstein DS. Glycine stimulates striatal dopamine release in conscious rats. Br J Pharmacol. 1993 Sep;110(1):50-3.
 Molander A, Söderpalm B. Glycine receptors regulate dopamine release in the rat nucleus accumbens. Alcohol Clin Exp Res. 2005 Jan;29(1):17-26.
 Previc FH. Dopamine and the origins of human intelligence. Brain Cogn. 1999 Dec;41(3):299-350.
 Verendeev A, Sherwood CC. Human Brain Evolution. Curr Opin Behav Sci. 2017 Aug;16:41-45. doi: 10.1016/j.cobeha.2017.02.003. Epub 2017 Mar 31.
 Previc FH. Thyroid hormone production in chimpanzees and humans: implications for the origins of human intelligence. Am J Phys Anthropol. 2002 Aug;118(4):402-3; discussion 404-5.
 Previc FH. A general theory concerning the prenatal origins of cerebral lateralization in humans. Psychol Rev. 1991 Jul;98(3):299-334.
 Previc FH, Declerck C, de Brabander B. Why your "head is in the clouds" during thinking: the relationship between cognition and upper space. Acta Psychol (Amst). 2005 Jan-Feb;118(1-2):7-24. Epub 2004 Nov 23.
 Previc FH. Prenatal influences on brain dopamine and their relevance to the rising incidence of autism. Med Hypotheses. 2007;68(1):46-60. Epub 2006 Sep 7.
 Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23.
 Mishra A, Singh S, Shukla S. Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease. J Exp Neurosci. 2018 May 31;12:1179069518779829. doi: 10.1177/1179069518779829. eCollection 2018.
 Rangel-Barajas C, Coronel I, Florán B. Dopamine Receptors and Neurodegeneration. Aging Dis. 2015 Oct 1;6(5):349-68. doi: 10.14336/AD.2015.0330. eCollection 2015 Sep.
 Solinas M, Belujon P, Fernagut PO, Jaber M, Thiriet N. Dopamine and addiction: what have we learned from 40 years of research. J Neural Transm (Vienna). 2019 Apr;126(4):481-516. doi: 10.1007/s00702-018-1957-2. Epub 2018 Dec 19.
 Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PR. The dopamine theory of addiction: 40 years of highs and lows. Nat Rev Neurosci. 2015 May;16(5):305-12. doi: 10.1038/nrn3939. Epub 2015 Apr 15.
 Chen W, Nong Z, Li Y, Huang J, Chen C, Huang L. Role of Dopamine Signaling in Drug Addiction. Curr Top Med Chem. 2017;17(21):2440-2455. doi: 10.2174/1568026617666170504100642.
 Schretlen DJ, van der Hulst EJ, Pearlson GD, Gordon B. A neuropsychological study of personality: trait openness in relation to intelligence, fluency, and executive functioning. J Clin Exp Neuropsychol. 2010 Dec;32(10):1068-73. doi: 10.1080/13803391003689770. Epub 2010 Apr 19.
 Deyoung CG. The neuromodulator of exploration: A unifying theory of the role of dopamine in personality. Front Hum Neurosci. 2013 Nov 14;7:762. doi: 10.3389/fnhum.2013.00762. eCollection 2013.
 Previc FH. The role of the extrapersonal brain systems in religious activity. Conscious Cogn. 2006 Sep;15(3):500-39. Epub 2006 Jan 24.
 Meiser J, Weindl D, Hiller K. Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34. doi: 10.1186/1478-811X-11-34.
 Juárez Olguín H, Calderón Guzmán D, ... Barragán Mejía G. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467. doi: 10.1155/2016/9730467. Epub 2015 Dec 6.
 Ko JH, Strafella AP. Dopaminergic neurotransmission in the human brain: new lessons from perturbation and imaging. Neuroscientist. 2012 Apr;18(2):149-68. doi: 10.1177/1073858411401413. Epub 2011 May 2.
 Iyengar B. The melanocyte photosensory system in the human skin. Springerplus. 2013 Apr 12;2(1):158. doi: 10.1186/2193-1801-2-158. Print 2013 Dec.
 Ono K, Viet CT, ... Schmidt BL. Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling. Sci Rep. 2017 Aug 23;7(1):9181. doi: 10.1038/s41598-017-09682-4.
 Jerardino A, Marean CW. Shellfish gathering, marine paleoecology and modern human behavior: perspectives from cave PP13B, Pinnacle Point, South Africa. J Hum Evol. 2010 Sep-Oct;59(3-4):412-24. doi: 10.1016/j.jhevol.2010.07.003.
 Klein RG, Steele TE. Archaeological shellfish size and later human evolution in Africa. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10910-5. doi: 10.1073/pnas.1304750110. Epub 2013 Jun 17.
 Loftus E, Lee-Thorp J, ... Sealy J. Seasonal scheduling of shellfish collection in the Middle and Later Stone Ages of southern Africa. J Hum Evol. 2019 Mar;128:1-16. doi: 10.1016/j.jhevol.2018.12.009. Epub 2019 Jan 10.
 Banday AA, Lokhandwala MF. Dopamine receptors and hypertension. Curr Hypertens Rep. 2008 Aug;10(4):268-75.
 Jose PA, Eisner GM, Felder RA. Regulation of blood pressure by dopamine receptors. Nephron Physiol. 2003;95(2):p19-27.
 Westbrook A, Braver TS. Dopamine Does Double Duty in Motivating Cognitive Effort. Neuron. 2016 Feb 17;89(4):695-710. doi: 10.1016/j.neuron.2015.12.029.
 Yoest KE, Cummings JA, Becker JB. Estradiol, dopamine and motivation. Cent Nerv Syst Agents Med Chem. 2014;14(2):83-9.
 Salamone JD, Pardo M, ... Correa M. Mesolimbic Dopamine and the Regulation of Motivated Behavior. Curr Top Behav Neurosci. 2016;27:231-57. doi: 10.1007/7854_2015_383.
 Castrellon JJ, Seaman KL, ... Samanez-Larkin GR. Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. J Neurosci. 2019 Jan 9;39(2):321-332. doi: 10.1523/JNEUROSCI.1984-18.2018. Epub 2018 Nov 16.
 Oberlin BG , Albrecht DS, ... Yoder KK. Monetary discounting and ventral striatal dopamine receptor availability in nontreatment-seeking alcoholics and social drinkers. Psychopharmacology (Berl). 2015 Jun;232(12):2207-16. doi: 10.1007/s00213-014-3850-5. Epub 2015 Jan 7.
 Kurniawan IT, Guitart-Masip M, Dolan RJ. Dopamine and effort-based decision making. Front Neurosci. 2011 Jun 21;5:81. doi: 10.3389/fnins.2011.00081. eCollection 2011.
 Di Domenico SI, Ryan RM. The Emerging Neuroscience of Intrinsic Motivation: A New Frontier in Self-Determination Research. Front Hum Neurosci. 2017 Mar 24;11:145. doi: 10.3389/fnhum.2017.00145. eCollection 2017.
 Kayser AS, Mitchell JM, Weinstein D, Frank MJ. Dopamine, locus of control, and the exploration-exploitation tradeoff. Neuropsychopharmacology. 2015 Jan;40(2):454-62. doi: 10.1038/npp.2014.193. Epub 2014 Jul 30.
 Ly V, Wang KS, Bhanji J, Delgado MR. A Reward-Based Framework of Perceived Control. Front Neurosci. 2019 Feb 12;13:65. doi: 10.3389/fnins.2019.00065. eCollection 2019.
 Kohno M, Ghahremani DG,... London ED. Risk-taking behavior: dopamine D2/D3 receptors, feedback, and frontolimbic activity. Cereb Cortex. 2015 Jan;25(1):236-45. doi: 10.1093/cercor/bht218. Epub 2013 Aug 21.
 Oswald LM, Wand GS, ... Brašić JR. Risky decision-making and ventral striatal dopamine responses to amphetamine: a positron emission tomography [(11)C]raclopride study in healthy adults. Neuroimage. 2015 Jun;113:26-36. doi: 10.1016/j.neuroimage.2015.03.022. Epub 2015 Mar 18.
 Costa VD, Tran VL, Turchi J, Averbeck BB. Dopamine modulates novelty seeking behavior during decision making. Behav Neurosci. 2014 Oct;128(5):556-66. doi: 10.1037/a0037128. Epub 2014 Jun 9.
 Zald DH, Cowan RL, ... Kessler RM. Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans. J Neurosci. 2008 Dec 31;28(53):14372-8. doi: 10.1523/JNEUROSCI.2423-08.2008.
 Ciarka A, Vincent JL, van de Borne P. The effects of dopamine on the respiratory system: friend or foe? Pulm Pharmacol Ther. 2007;20(6):607-15. Epub 2006 Oct 27.
 Cabezas GA, Israili ZH, Velasco M. The actions of dopamine on the airways. Am J Ther. 2003 Nov-Dec;10(6):477-86.
 Chester DS, DeWall CN, ... Jiang Y. Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation-seeking. Soc Neurosci. 2016 Oct;11(5):487-94. doi: 10.1080/17470919.2015.1119191. Epub 2015 Dec 7.
 Crockett MJ, Siegel JZ, ... Dolan RJ. Dissociable Effects of Serotonin and Dopamine on the Valuation of Harm in Moral Decision Making. Curr Biol. 2015 Jul 20;25(14):1852-9. doi: 10.1016/j.cub.2015.05.021. Epub 2015 Jul 2.
 Aberg KC, Doell KC, Schwartz S. The "Creative Right Brain" Revisited: Individual Creativity and Associative Priming in the Right Hemisphere Relate to Hemispheric Asymmetries in Reward Brain Function. Cereb Cortex. 2017 Oct 1;27(10):4946-4959. doi: 10.1093/cercor/bhw288.
 Lhommée E, Batir A, ..., Krack P. Dopamine and the biology of creativity: lessons from Parkinson's disease. Front Neurol. 2014 Apr 22;5:55. doi: 10.3389/fneur.2014.00055. eCollection 2014.
 Boot N, Baas M, ... De Dreu CKW. Creative cognition and dopaminergic modulation of fronto-striatal networks: Integrative review and research agenda. Neurosci Biobehav Rev. 2017 Jul;78:13-23. doi: 10.1016/j.neubiorev.2017.04.007. Epub 2017 Apr 15.
 Smillie LD, Wacker J. Dopaminergic foundations of personality and individual differences. Front Hum Neurosci. 2014 Oct 30;8:874. doi: 10.3389/fnhum.2014.00874. eCollection 2014.
 Fischer R, Lee A, Verzijden MN. Dopamine genes are linked to Extraversion and Neuroticism personality traits, but only in demanding climates. Sci Rep. 2018 Jan 29;8(1):1733. doi: 10.1038/s41598-017-18784-y.
 Cohen MX, Young J, ... Ranganath C. Individual differences in extraversion and dopamine genetics predict neural reward responses. Brain Res Cogn Brain Res. 2005 Dec;25(3):851-61. Epub 2005 Nov 11.
 Ashok AH, Marques TR, ... Howes OD. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Mol Psychiatry. 2017 May;22(5):666-679. doi: 10.1038/mp.2017.16. Epub 2017 Mar 14.
 Maier F, Merkl J, ... Timmermann L. Hypomania and mania related to dopamine replacement therapy in Parkinson's disease. Parkinsonism Relat Disord. 2014 Apr;20(4):421-7. doi: 10.1016/j.parkreldis.2014.01.001. Epub 2014 Jan 12.
 Kuo JR, Lin SS, .... Liu JM. Deep brain light stimulation effects on glutamate and dopamine concentration. Biomed Opt Express. 2014 Dec 3;6(1):23-31. doi: 10.1364/BOE.6.000023. eCollection 2015 Jan 1.
 Lima LAR, Lopes MJP,... Viana GSB. Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats. J Neuroinflammation. 2018 Aug 31;15(1):249. doi: 10.1186/s12974-018-1266-6.
 Sedaghat K, Yousefian Z, ... Choobdar S. Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat. Behav Brain Res. 2019 Jan 1;356:156-169. doi: 10.1016/j.bbr.2018.08.020. Epub 2018 Aug 23.
 Kesby JP, Turner KM, ... Burne THJ. Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain. Int J Dev Neurosci. 2017 Nov;62:1-7. doi: 10.1016/j.ijdevneu.2017.07.002. Epub 2017 Jul 14.
 Ziomber A, Thor P, ... Antkiewicz-Michaluk L. Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures. Pharmacol Rep. 2012;64(6):1359-67.
 de la Presa Owens S, Innis SM. Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. Nutr. 1999 Nov;129(11):2088-93.
 Zimmer L, Hembert S, ... Chalon S. Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. Neurosci Lett. 1998 Jan 16;240(3):177-81.
 Ahmad SO, Park JH, Radel JD, Levant B. Reduced numbers of dopamine neurons in the substantia nigra pars compacta and ventral tegmental area of rats fed an n-3 polyunsaturated fatty acid-deficient diet: a stereological study. Neurosci Lett. 2008 Jun 27;438(3):303-7. doi: 10.1016/j.neulet.2008.04.073. Epub 2008 Apr 25.
 Kuperstein F, Yakubov E, ... Yavin E. Overexpression of dopamine receptor genes and their products in the postnatal rat brain following maternal n-3 fatty acid dietary deficiency. J Neurochem. 2005 Dec;95(6):1550-62. Epub 2005 Nov 23.
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