Qualia Immune Review: Vibrant Trendsetter For More Resilience & Immune System Adaptability?

The art, or science, of training your immune system is as old as history. In ancient times, the king of Pontus, Mithridates II, regularly took a cocktail of 65 ingredients to protect himself against poisoning (1).

Of course, “poisoning” is somewhat different from a simple immune response.

And yet, both the principle of protecting yourself against poisoning and keeping your immune system primed for all it will encounter, has similarities: keeping the organism healthy and resilient.

And, obviously, I don’t recommend Mithridates' approach either!

But what is the ideal approach to valuing our immune health in modern times? 

The comprehensive formulas made by Neurohacker Collective are taking on that challenge for the ideal, well-rounded immune support formula for today’s world: Qualia Immune contains 19 different ingredients to support your immune system in the most essential ways necessary. 

The name of the formula is Qualia Immune, and it aims to support a host of immune functions: renewal of immune cells, ensuring immune cells work properly and making sure the immune system learns to identify and optimally address as many challenges as possible which encounter it.

(You can click HERE to get Qualia Immune - use discount code FERGUS to save 15%)

Let’s take a deep dive into the ambitious list of goals Qualia Immune seeks to accomplish. The Qualia Immune Whitepaper specifically states that the goals of this formulation are to:

(Note: don’t be intimidated by the complex terminology, I’ll break these concepts down into more details later on):

 

WHAT DOES QUALIA IMMUNE DO?

 

Supports general immune health and wellness*

Supports a healthy immune system during aging*

Supports year-round immune health at all ages*

Supports seasonal health and well-being*

Supports key immune cells*

Supports the body’s natural defenses*

Supports the immune system during periods of intense exercise

and training*

Supports healthy working days and work productivity*

Supports digestive tract health*

Supports respiratory tract health*

 

 

HOW DOES QUALIA IMMUNE DELIVER ADVANCE IMMUNE SUPPORT?

 

By supporting a “youthful” immune system, i.e., countering

immunosenescence*

By supporting immune system intelligence, i.e., immuno-learning

and memory*

By supporting recognition of new antigens*

By supporting immune tolerance, i.e., appropriate non-reactivity to

self*

By supporting mucosal immunity. i.e., barrier immunity*

By supporting gut microflora, i.e., gut-immune intelligence*

By supporting hematopoietic stem cell function, i.e., generation of

immune cells*

By supporting immune system fitness, i.e., trained immunity*

By supporting immune system communication*

By supporting dendritic cell (DC) number & function*

By supporting toll-Like receptor (TLR) expression/function

By supporting natural killer (NK) cell function*

By supporting macrophage function*

By supporting microglia function i.e., the brain’s immune system*

By supporting neutrophil function*

By modulating mast cell, basophil, and eosinophil responses

By supporting gamma delta T cells (γδ T cells)*

By supporting naïve T cells*

By supporting CD8+ T cell function*

By supporting antibody response to new immune challenges i.e., B

cell function*

By supporting Nrf2 i.e., a master regulator of cellular defenses

By supporting healthy mitochondria i.e., immune cells need & use

energy

By supporting healthy cortisol and testosterone levels*

 

 

That’s a crazy list, right?

And yet, Neurohacker, and specifically, Greg Kelly (ND), does an admirable job at referencing tons of supporting science for those goals (2).

So, in this blog post, I’ll be reviewing the science behind the formula’s goals outlined by Dr. Greg Kelly.

I do want to say, upfront, that I’m not an expert on the immune system - my Master's specialization is in health science & philosophy of science and technology, among others. The only thing I can do is triangulate the statements made in the whitepaper with currently available scientific evidence.

Also, a note regarding my personal experience with this stack. Unlike a nootropic stack or energy stack, an immune stack is not designed to give off a noticeable subjective experience, so it would be a total misunderstanding of the formula’s purpose to ask yourself “what you notice” while taking it.

A good immune stack is defined less by what subjective effects, and more by the science of the formulation supporting its value to your immune system. 

 

Here’s the Table of Contents of my article: 

Table Of Contents

  1. Introduction: Why Develop An Immune System Support Stack?
  2. The Science Review Of Qualia Immune's Ingredients
  3. Overall Verdict: What Do I Think About This Supplement'S Quality?
  4. Finishing Thoughts

 

Hope that got you curious!

Let's go:

 

Introduction: Why Develop An Immune System Stack?

Why develop an immune system stack?

The answer is simple: sub-optimal immune function not only leaves general health in a less robust state, but anything the immune system encounters is more taxing on optimal health when immune robustness begins the encounter at a mediocre level of function.

Everything from missed work to delayed general life goals cost enormous amounts of money and quality of life enjoyment when viewed through the longview of an entire lifespan. So anything we can do to bring our immune function from average to exceptional more than pays for itself over the long haul.

 

(Note: Qualia Immune is not a medication nor is it aimed to treat or cure any medical condition. Rather, Qualia Immune is a supplement for healthy people looking to take their immune function from a state of average baseline health, to a state closer to truly optimal function. If you have any questions concerning if Qualia Immune is right for your unique health status, consult your physician). 

 

Why the focus on the immune system? Well, at a very basal level, having an optimally functioning immune system is a game-changer.

Let's explore why through the concept of “resilience” (4; 5; 6). Common definitions of resilience mostly focus on “bouncing back” after (mental) hardship but I’d define the concept as an excess bodily and mental capacity that allows you to be less affected by environmental, biological, and other challenges from daily life.

So, by becoming more resilient an organism increases its overall ability to adapt

For instance, once you supply our body with optimal levels of vitamin C, D, vitamin B6, B9 (folic), zinc, magnesium, and a whole bunch of other nutrients, your overall resilience increases dramatically (7; 8; 9).

Yes, your immune system might be doing great once you’re consuming adequate levels of zinc and magnesium. But, adequate levels are very different from optimal levels.

Next, there’s the fact that many plant compounds can affect overall immune system functioning - many of them I’ll review in-depth in the next section. If you’re not ingesting many of these plants - potentially as supplements - then obviously you’re missing out on the benefits they confer.

And yet, from the perspective of their immune system, tons of people are getting through life alternating between one foot on the gas and one foot on the brake.

Phrased differently: many people are not doing as well as they could!

Hence, by doing just good and optimal are two very different things. Here's where the creators of Qualia Immune come in:

The supplement is not merely aimed at providing your body with a few nutrients so that your immune function works better, or supply you with a few adaptogens to lower your stress levels.

(You probably know that chronic stress is very bad for your health, and, the science supports that claim (111213). If you like to learn more about lowering stress, read THIS series on the topic!)

No, Qualia Immune's goal is far more comprehensive. Let's consider the argument in the next section!

 

Qualia Immune White Paper Explained

As I've stated before, Greg Kelly has written an insanely interesting white paper that explains his thoughts behind formulating Qualia Immune (2). Of course, Greg probably has a whole team behind him but as the paper is published in exclusively his name, I'm going to consider it his work.

The basic argument is this:

Your immune system exhibits intelligence, just like your human brain does. Next to your environment, the way you live, your thought patterns, what you put in your body also affects that immune system.

So far, simple, right?

If you don't consume sufficient vitamin C, many aspects of your immune system don’t perform as well as they can - everybody understands that (1415). And yet, many people under-consume the vitamin and don’t even ingest adequate amounts, let alone optimal!

And, as it turns out, many other compounds may support immune function as well! Plants, such as adaptogens or fibers found therein, can have a huge impact on immune function.

All these compounds ensure that we have to start imagining the immune system in novel ways.

Once you conceive your "immune system" as "intelligent", it opens up the door to a whole new way of interpreting its function. Now, the immune system can memorize, grow, learn, and adapt over time.

Let's make an analogy:

Remember that your brain is subdivided into different parts and different categorizations (such as opposing the primordial brain stem with basic functions like temperature with the dopamine system involved with complex thought).

So, you've got parts of your brain involved with similar functions that lower mammals and many other biological organisms exhibit. And, on the other hand, you've got parts of your brain that help you plan, simulate counterfactuals, apply logic, reason, and strategize (1617).

In the same way, your immune system is made up of many different parts.

You've got the more primitive "innate immune system", and, the later evolutionary development of the "adaptive immune system" (18192021).

And while Greg Kelly uses his own analogies to describe that difference, such as Daniel Kahneman's Thinking, Fast and Slow and Nassim Taleb's AntifragileI'll use my own.  

To me, everything in this universe seems to be capable of evolution - not only biological organisms (256257258259260). There once was a time where no planets existed, and now they do. There once was an Earth without life, and now there is life. And on that Earth, not only the biological organisms are evolving, but, even the atmosphere, the inorganic sea with changing chemical elements over time, and many other systems.

The human immune system evolves over time as well and even needs to, for humans to survive. There was a time, 600 years ago, you and I had very different challenges to our immune system than people do today.

The many parts of the immune system, such as white blood cells (macrophages, T-cells), lymphocytes like Natural Killer (NK) cells, the mucous environment in your nose, your gut function, all evolve. What's more, these compounds evolve together with the entire human organism. 

Of course, many parts of that evolutionary process are very slow, such as changes in bone structure or organ function through Darwinian evolution over the course of many generations.

But, not only does your immune system evolves during your life, but it also does during different generations. Let's view a broader perspective though:

Put more simply, everything in the universe changes, including foreign substances and other challenges for your body, and as a result, your body and your immune system also has to evolve (learn, adapt). The better you adapt, in turn, the more you'll thrive.

The simple fact that your adaptive immune system not just responds, but plans and strategizes against invaders over time, demonstrates that your immune system is inherently intelligent, not just an entity or collection of entities that respond to a stimulus. 

Greg Kelly, aptly describes that dynamic in the following way, regarding the immune system's ability to think (2):

 

From birth till death, the immune system must stay constantly alert, sensing what is going on inside and outside the barriers of the body. And, it is involved in an ongoing process of making decisions, determining what to pay attention to (non-self) and what to safely ignore (self and helpful organisms like commensal bacteria in the gut microbiome).

To do its job the immune system needs to be able to recognize and respond to new information. Molecular patterns are information in the immune system’s world. Processing speed, the ability to rapidly recognize and respond to minor differences in molecules, is essential.

The immune system is brilliant when it comes to recognizing patterns. It’s ability to detect and recognize patterns, figuratively searching for and finding needles in haystacks of molecules—self molecules far outnumber non-self—allow it to quickly identify molecular situations that require its attention, while ignoring all the molecules that don’t.

Dealing with change, meeting unanticipated challenges, and remaining flexible as circumstances evolve … if there were a job description for the immune system, these would be essential requirements.

Over the course of a lifetime the immune system must learn and be able to store and recall information about millions of different molecular patterns. And it will remember what it learns for decades, still being able to recall and use information in old age that it learned in early childhood. 

 

Hence, your immune system is fundamentally different at age 1, 20, and 60, due to everything it has learned.

Qualia Immune aims to optimize that learning process within the immune system. If you're interested in buying Qualia Immune then use discount code FERGUS to save 15%.

Next up, let’s take a deep dive into this formula:

 

Science Review Of Qualia Immune's Ingredients

The moment of truth: 

In this section I'll review the 19 ingredients within Qualia Immune. 

I won't state whether studies on animals or with human participants are used for all of the scientific statements about their supplemental strategy. Doing so breaks readability too much, in my opinion. Instead, you can simply click my references and check whether it's an animal study or one with human participants yourself.

I will say that many of Neurohacker’s more scientifically speculative strategies are based upon animal studies - not all strategies implemented by Neurohacker can be confirmed by human studies yet. Whether Neurohacker's inferences are reasonable, or not, I will consider after showing you all the data.

Here we go, a review of all 19 ingredients in Qualia Immune (if you're interested in the product, then use discount code FERGUS to save 15%):

 

1. Vitamin D, As Cholecalciferol, 20 Micrograms (mcgs), 800 International Units, 100% of Daily Value (DV)

Vitamin D's role in the immune system has gotten tremendously famous lately. The vitamin plays a major role in mounting an optimized immune response to anything it encounters since the earliest days humans roamed the planet (222324).

It's extremely likely that vitamin D plays a role in the prevention of the so-called "cytokine storm" (2526). Cytokines are messenger cells in your immune system. When you've got adequate levels of cytokines your immune system essentially works more efficiently because having high levels of cytokines isn’t “cost-free”. 

Also, vitamin D has a huge effect on the "adaptive immune system" - the immune system that learns over time (27). B cells and T cells are mainly responsible for that effect.

Also, there's a long tradition of associating correct vitamin D levels with optimizing the immune system the correct identifying of the body’s own cells versus non-self (28293031). Correct vitamin D levels, therefore, improve your immune system to steer clear from incorrectly categorizing your body’s own cells.

Nevertheless, the use of oral vitamin D is more controversial, in my opinion. This is a minority view within science, right now, though.

The thesis entails that the 25-hydroxy form of vitamin D is probably not the true storage form, and that many people oversupplement with vitamin D, leading to health problems down the road. The true long-term storage form of vitamin D is not yet possible to measure, leading people to take in levels that can normally not be achieved through sunlight exposure.

(Vitamin D creation through your skin has a negative feedback loop, meaning that your body will shut down production after time once your levels become high. With oral vitamin D supplements, that's not the case).

If you're interested in that thesis, read more on THIS Facebook page.

Also, in the past, I've advocated for getting your vitamin D levels from sunlight exposure whenever necessarynot from a pill.

Additionally, Qualia Mind has 1,000 international units (25 micrograms) of vitamin D as well. Because Neurohacker recommends combining these products, people would ingest 1,800 international units per day, with continuous use, which could be excessive if you're already getting lots of sunlight exposure or vitamin D through your diet.

Nonetheless, vitamin D plays many important roles in the immune system, such as:

  • Supporting the role of "microglia", which act as a defense in the central nervous system (3233). Your brain and spinal cord make up that central nervous system. It's very likely that through optimizing microglia function, the body is better able to identify your body’s own cells as not needing intervention by the immune system.
  • Enhancing "natural killer cell" activity (3435). Natural killer cells clean up damaged and stressed cells. The natural killer cells are part of the quicker "innate immune system". With optimal vitamin D status, you'll literally have higher levels natural killer cells present in your body (36).
  • With regard to the T-cells, of the slower adaptive immune system, higher vitamin D status also improves functioning there (373839). T-cells often take weeks to learn about a new challenge to the immune system, but, then provide immunity (so, a targeted response) for decades to come! The same is true for B-cells and vitamin D status (404142). Correctly trained B-cells, in turn, may also play a role in steering parts of the immune system away from targeting your body’s own cells.
  • Vitamin D also plays a role in optimizing mucosal integrity (434445). You've got mucosal lining in your gut, for instance, where your immune system also plays a role. Remember that quote that immunity starts in your gut? I don't agree with the quote, but, there is some truth to it. Studies since 2010 on this topic confirm this important link. Simply put, with proper vitamin D status, your gut barrier is less likely to let anything through that shouldn't pass in the first place. 
  • "NRF2", which is a pathway involved with detoxification, cell defence, stress response, your body's antioxidant levels, repair, etcetraNRF2 regulates many other processes in your body as well. Vitamin D, in turn, plays a role in the NRF2 pathway (464748). While many more studies need to investigate this link, it's reasonable to suspect vitamin D does indeed play a role here!

Now, here's where I will compliment Neurohacker: the excellent whitepaper treats all these topics I've listed above. I've double-checked the statements about the supplemental strategy of Neurohacker and they're all correct. 

In my process, I didn't use the reference list of Neorohacker but searched for evidence in PubMed myself. Hence, not all citations I use are similar to Neurohacker, and vice versa.

Verdict: very important compound, but, I would personally not have included vitamin D in an immune supplement, because I don't think oral vitamin D is fully benign. I will say that vitamin D's role in retaining optimal immune system is almost all-encompassing, ranging from mucosal immunity to T and B-cell training to NRF2 and many other domains.

 

 

2. Zinc Gluconate, 15 Milligrams (mg), 136% of DV.

Zinc...

Another compound that many people have spoken about lately! I've actually written a 3-part series on zinc that explains the health effects and background of this mineral in extreme detail.

And in my blog about zinc supplements and lab testing, I actually consider "zinc gluconate", which is included here, as one of the best zinc forms in existence!

The bad part?

I'm not a fan of including just one mineral in the absence of others, especially if you don't know the zinc status of the person taking the supplement. Qualia Immune contains a whopping 136% of the recommended Daily Value (DV) of zinc.

What is known, for instance, is that zinc directly interacts with your copper and iron status (4950515253). Most studies show that supplementing with zinc lowers your copper status over time, for instance - although not all studies agree. The same may be true for iron when zinc is supplemented, although less data is available.

I actually recommend removing zinc from this supplement. Why? Taking Qualia Immune at a schedule of 5 days on, 2 days off, will drive nutritional excesses and/or imbalances over time, especially if this supplement is used for months or years on end.

I'm sorry to be so direct but that's my honest opinion.

In foods, zinc is almost always paired with iron and copper in different ratios. In this supplement, however, there's no iron and no copper, leading to an increased risk of creating imbalance over time.

Also, for people who are already consuming enough zinc, which I guesstimate as 80% of the population in the developed world, I don't think there are any benefits to supplying more and I think adding more actively harms people. Many people taking Qualia Immune are therefore almost certainly already including sufficient zinc in their diets and adding more is not necessarily benign.

Having said that, the foundational role of zinc in optimizing the immune system is pretty clear:

  • Zinc has huge effects on how well your immune system functions (545556). Zinc plays a role in communication between immune cells, for instance, as well as the creation of immune cells, the process of differentiation into other types of immune cells, and their survival. As a result, if you’ve got optimal zinc levels, you're less likely to be affected by challenges to the immune system because your overall resilience is much greater.
  • Zinc influences how well your neutrophils function (575859). Neutrophils have different functions, such as "phagocytosis" (eating foreign compounds), "degranulation" (which counters infections), and more (60). How do you know zinc plays a role? Simple: neutrophils are rich in zinc themselves, and, neutrophils can actually be used to test for your zinc status! Zinc deficiency seems to be tied to that inability to deal with new challenges.
  • "Macrophages" are yet another white blood cell which are dependent on zinc status (61626364). Macrophages also engage in the "phagocytosis" process I talked about before, which is the "eating" of dangerous or no longer necessary compounds so that they can be cleared from the body. You'll also supports a normal cytokine response with sufficient zinc. Recall that cytokines help your immune system communicate and optimizing their function will improve all aspects of your immune system. 
  • Just like the earlier "macrophages", the "natural killer cells" are also dependent on zinc (65666768). Some research does contradict this finding. Natural Killer Cells are part of the innate - or quickly-acting - immune system.
  • T cells, which are part of the slower "adaptive immune system", function more properly with sufficient zinc as well (69707172). As a result, your body is more able to distinguish between your body’s own cells and foreign substances. Also, zinc improves cytokine function (messenger within the immune system), and the body's ability to learn from past infections. Even transplants are more readily accepted with zinc adequacy.
  • Once again, zinc also plays a role in the optimal functioning of the NRF2 system (737475). Recall that NRF2 is involved with detox, your antioxidant system, hormones, etcetera.
  • Zinc is depleted with chronic stress and exercise, and may buffer your ability to deal with them (7677). Lowering psychological stress (especially chronic), in turn, also increases your chances of having an immune system that functions properly (7879). The better you can counter chronic stress and overtraining after exercise, the more apt your entire organism can function even at an immune system level.
  • Once you get older, zinc deficiency becomes more common (808182). You'll be more at risk of having a zinc deficiency when you age because absorption goes down over time. For that reason, I think it's less suboptimal for Neurohacker to include zinc in this product than for younger people.

Conclusion?

Zinc's role in a properly functioning immune system is very clear!

Verdict: zinc is essential for an optimally functioning immune system. Neurohacker also included the right zinc form that is highly absorbable. And yet, I would not include zinc gluconate at all, especially not at the 15-milligram dose, because of the risk of creating iron and/or copper imbalances over time.

 

Note:

From this point going forward, I will review each compound less extensively than I did with vitamin D and zinc. I will randomly pick 2-3 supplement technology strategies for each ingredient and consider their truth from the perspective of the scientific literature.

I've used the "random number generator" to pick which statements to review. So, the Qualia immune whitepaper mentions "selenium" 11 times, and therefore, I've picked 3 random numbers between 1 and 11. If a number is selected twice, I'll pick a random number again, until I've got 3 different numbers.

When there's a very famous property of an ingredient, like ginseng's effect on fatigue, I have prioritized that property.

Here's the rest of my review:

 

3. Selenium, As Se-Methyl-L-Selenocysteine, 55mcg, 100%

Credit where credit is due: this form of selenium, not dosed in very high quantities, is a perfect addition to Qualia Immune!

With selenium, there's also less risk of interaction with other nutrients, as there was with zinc.

Selenium, as a mineral, is tricky (8384). Soil content varies very widely, with differences of up to 450-fold in selenium soil content, according to Dr. Chris Masterjohn. A 30-fold difference is more reasonable to assume, however, but it's still very high.

Testing your selenium status is therefore the best solution to know whether you're getting enough. Eating tons of brazil nuts and other nutrients can therefore backfire as you don't know whether you've got excessive levels.

Also, excess selenium has been noted due to supplementation, although, exceedingly rare and usually due to low-quality supplements (85868788). Nonetheless, 5-15% of people in the developed world have selenium deficiencies, and more in developing countries (89). Increasing selenium intake therefore will support optimal immune function in a broader category of the population.

So let's dig a bit deeper into this nutrient:

  • Just like zinc, selenium is also necessary for a generally properly working immune system (9091929394). The most basic antioxidant, "glutathione", depends on selenium, for instance. Links between antioxidant function - which prevent excess "free radical" buildup as a side-effect of energy generation by your cells - are linked to proper immune function (9596). "Neutrophils", which are part of the innate immune system, also function better with sufficient selenium. Why? Simple: free radicals can also be produced when immune cells "eat" substances the immune system identifies as “non-self” as opposed to ”self”. Selenium is also necessary for the Natural-Killer (NK) cells and T-lymphocytes.
  • Other cells such as eosinophils, basophils and mast cells also depend on selenium (979899100). Translated to plain English, there's evidence that selenium is a necessary building block for many different types of immune cells and processes.
  • An optimal immune response and properly functioning cytokines are also supported by selenium (92). So there's less risk of your immune system going "haywire" with optimal selenium status. Simply put, without sufficient selenium, your immune cells won't differentiate into more specific cells as well as they should, and they won't be activated and/or won't proliferate as readily as they should. In plain English, your immune system will have a more calculated and measured response with proper cytokine function.

If those sentences make it sound like selenium is an important compound in your immune system, then I've achieved my goal!

Verdict: even though supplementing with selenium for longer periods of time will put many people at risk for an excess, the dosage of selenium in Qualia Immune is not so high that it becomes problematic. Also, Neurohacker correctly identifies selenium as a quintessential compound for proper immune function. Their statements that selenium is necessary for many different cells, such as mast cells, T-lymphocytes, eosinophil, etcetera, are correct.

 

4. Reishi Mushroom (Ganoderma Ludicum), Fruiting Body Extract, 400 mg

Reishi has become insanely popular in the last decade, in part, because of its broad-spectrum effect upon the immune system.

And yes, as always, much of the high-quality research with a sufficient number of human participants and proper study setups are lacking. Nevertheless, it's still possible to reconstruct a plausible account of how Reishi is interacting with human physiology generally, and the immune system in particular.

For instance:

  • A couple of studies demonstrate a positive effect of reishi mushrooms on a process called “autophagy” and “apoptosis” (101102). With those processes, defective cells are either cleaned up and recycled or killed by your cells. Moreover, levels of cytokines are normalized, for instance, thereby making it less likely a  "cytokine storm" in an immune system has an unmeasured and excessive response. Natural killer cells, part of the innate immune system, also did their job better.
  • Reishi almost certainly increases exercise tolerance while lowering fatigue and stress (103104105106107). Stress is a huge component in assuring proper immune function. Overall mood may also improve, which, is a plus for immune function! Decreasing your susceptibility to stress and boosting exercise tolerance also translate into a more optimally functioning immune system.
  • Reishi consumption may lead to a more favorable composition of T-lymphocytes (108). Recall that the t-lymphocytes are the part of the immune system that learn to recognize new challenges over time that your innate immune system doesn't immediately deal with. Overall, the learning ability of the immune system thereby goes up.
  • "Dendritic cell" function is also aided by consuming reishi (109110111112). Dendritic cells mediate the innate and adaptive immune system, by "eating" substances that are challenges to the immune system or need to be cleaned up. Dendritic cells are also helping B and T cells learn about the properties of such challenges. The carbohydrates in reishi, called "polysaccharides", are partially responsible for this effect.

And the dose? 400 milligrams taken daily might not be the highest dose found on the market - many products use a 1,000-milligram dose - but, within the context of 20 different ingredients, it will be a huge contributor.

Remember that Neurohacker probably aims to have all these compounds working together, instead of considering them in isolation.

Verdict: thumbs up! Even though I haven't researched all of Neuorhacker's claims regarding this compound, as doing so would entail me writing a book-long blog post, the statements about Neurohacker’s supplemental strategy made in the whitepaper are valid. Reishi is an excellent compound for any immune-health promoting product.

 

5. Palmitoylethanolamide (PEA), 300 mg

Palmitoylethanolamide is very interesting as a compound! For instance, the substance can improve the "entourage effect" of combining different cannabinoids (113114). That entourage effect entails that by combining different compounds in cannabis, like THC and CBD, the biological effects are amplified.

Nevertheless, this compound hsa many other biological effects:

  • Palmitoylethanolamide (PEA) regulates mast cell function. Mast cells play a major role in your "histamine" system, which, has a close relationship to immune function and increasing the ability of the immune system to create sensitivity to the correct compounds (115119). If your histamine system functions optimally, for instance, you will more perfectly digest wine or fermented foods. The better mast cells are regulated, the more likely they cause optimization downstream, such as lower histamine levels.
  • PEA seems to have the ability to make the immune system healthier overall (116117). This research is preliminary, however, but promising, and exact mechanisms aren’t fully understood yet.
  • A healthy restorative and regenerative response might be enhanced by PEA (118119120121122123). The human healing response combines the functioning of the immune system, circulation, and potential molecular intermediaries. As a result, old or damaged tissues are more easily cleared.
  • Lastly, cytokine communication may also be optimized by PEA, so that parts of the immune system can better communicate (124125126). 

The dose is decent, with 300 milligrams. Studies generally use 300-1,500 milligrams, and hence, Neurohacker's product falls within that range.

Verdict: great, promising compound, that's dosed properly. PEA seems like a perfect compound to increase how your immune system is regulated and also has some positive "endocannabinoid" effects, it seems.

 

 

6. Tinofend®Tinospora cordifolia Stem Extract, 300mg

Tinospora cordifolia certainly is an interesting compound. The plant comes from tropical regions in India, and has been used for centuries in Aryuvedic medicine. Unfortunately, there's not much high-quality research on this compound - even less so than other compounds treated in this blog post (127).

Let's look at some effects though:

  • The overall picture of Tinospora cordifolia is that it supports both the evolutionary older "innate immune system" and the newer "adaptive" one (128129130). Neutrophils, T and B cell differentiation, cytokine levels, and macrophages all seemt o be affected.

    One study goes as far as saying:

"[U]sages as anti-oxidant, anti-hyperglycemic, antihyperlipidemic, hepatoprotective, cardiovascular protective, neuroprotective, osteoprotective, radioprotective, [...] adaptogenic agent, [...]. The plant is also a source of micronutrients viz. copper, calcium, phosphorus, iron, zinc and manganese. A special focus has been made on its health benefits [...] and its potential as an immune booster [and] aiding in the betterment of human life expectancy." (129)

I, personally, don't think these qualities are proven beyond any reasonable doubt - and don't even stand scrutiny against some doubt. Having said that, the plant may have benefits but it's very speculative as of this moment.

  • Having said that, I'm less sceptical than the average "evidence-based" researcher who demands multiple "randomized controlled trials" with a high quantity of participants before assuming any compound has any effect.

    I do see value in medical traditions such as Ayurveda and think they may be complementary to Western science in some regards (131132133134). I do think that Ayurveda in some way systematizes observations made through centuries if no millennia, although, not with the rigor of Western placebo controls, statistics, and more.

  • Caveat: many other studies can be found on this compound, although, they still suffer from the argument on quality I've made many times (135).

The dose is a bit low given that the compound is normally taken 3 times a day at 300 milligrams, but, given that ~20 ingredients all work synergistically in Qualia Immune, I'll give this a thumbs up!

So, my final judgment?

Verdict: interesting compound that needs more scientific validation with regard to the immune system, although, it could certainly be promising.

 

7. Wellmune®Baker's Yeast Beta Glucan, 250 mg

Beta glucans are a type of carbohydrate you find in oatmeal, mushrooms, and baker's yeast.

Simple, right?

The compound has a huge effect on the immune system, however, so that some calls exist to treat it as a "drug" instead of a "supplement" (136).

To give you an impression, the following chart displays the places in the immune system where beta glucans currently exhibit a proven effect:An external file that holds a picture, illustration, etc.
Object name is molecules-24-01251-g001.jpg

Source: (136)

 

So, let's, therefore, look at some of beta glucans' effects:

  • Beta glucans aid in the creation of immune cells from stem cells (137138139140). As a result, your body will be more able to create new white blood cells from the stem cells found in your bone marrow, among others. The stem cells themselves might also be created in greater quantities with beta glucan consumption. As a result, your body will be able to make more white blood cells which later differentiate into specific immune cells.
  • Also, because beta glucans are fiber-y compounds, they affect gut function. As a result, the immune system is also affected, given that gut function plays a major role in the immune system (141142143144). One specific effect of beta glucans is that they change the makeup of your gut bacteria, in part, because they're fibers that are very hard to digest, akin to "resistant starch" (145146). Many studies show that having improved gut function is intertwined with a more optimal immune response. 
  • I've not spent hours researching the effects of beta glucans on the immune system, but, as far as I can tell from preliminary investigations, currently available research is impressive and very promising.

The dose? Normally 1,000 - 2,000 milligram doses of this compound per day are taken. Here, Neurohacker included 250 milligrams, but, I'm pretty sure it's mostly because of the effects on the gut biome and immune system learning. 

 

**Update on dosing: Neurohacker e-mailed Alexfergus.com and stated that the Wellmune doses in studies, as proprietary formula, are in the 250 milligram or slightly higher range. I agree with their assessment and therefore reverse my earlier judgment that the beta glucans are underdosed. Looking at the Wellmune studies, the dose is perfect. I've kept the rest of this text the same so that the reader understands how my initial assessment is incorrect**

 

Many of the higher-dosed studies have been carried out regarding beta glucan and blood sugar management. I'm pretty sure that for tasks such as teaching your immune system to identify the correct compounds to remove, very high doses aren't necessary.

Also keep in mind that many of the other 19 ingredients in Qualia Immune overlap with the goals of beta glucan.

Verdict: excellent choice of ingredient that has decent scientific backing even today. 

 

8. Echinacea purpurea Root Extract, 200 mg

Echinacea Is a plant compound that many people take for their immune system in the Netherlands - I'm originally from that location.

Nevertheless, Echinacea is not just one plant but a collection of them. A similar idea would be to talk about "potatoes" - not all potatoes are the same either!

I was surprised, however, how much research can be found on this compound. Let's dig into that research:

  • By taking Echinacea, the overall efficiency of your immune system goes up (250251252). Therefore, you’ll recover quicker overall and are better. Also, the more efficient your immune system works, the more likely you’ll perform at a high level overall. 
  • Limited reserch shows that Echniacea aid dentritic cell function  (253254). Dendritic cells are part of the innate immune system but help the adaptive immune system in their learning process.

The dose? Doses are very hard to establish because different dosing methods all lead to different results. What also matters is how and where you source the Echniacea (255). 

400-milligram doses are pretty common in the Netherlands where I lived, so I don't expect any problems with the 200-milligram dose included here.

Verdict: interesting compound that probably has beneficial effects on the immune system, although more research is needed.

 

9. L-Theanine, 150 mg

Theanine, one of my favorite compounds in biohacking. Theanine works wonderfully well for type-A (or rather type triple-A) personalities like me because it promotes relaxed focus - instead of the more stress-based focus of caffeine (147148149).

I did notice one thing though, immediately, when I saw that theanine is included in this product. Qualia Mind also uses 200 milligrams of L-theanine and Qualia Night another 50 milligrams. 

The daily total would amount to 400 milligrams, if a person used Qualia Mind, Night, and Immune, as Neurohacker recommends. The problem with these dosages is that in some people, side-effects can occur, at 300 or 400 milligrams per day (150).

For me, a 220-pound+ male, that dose isn't an issue, but for a 60-kilogram female with low blood pressure and parasympathetic dominance, it can be. The solution isn't simple though, as removing theanine from any of these 3 supplements makes the individual supplement less effective, perhaps while boosting the efficacy of the combination of Mind, Night, and Immune.

Also, in most studies, however, 400-milligram doses of theanine are considered safe (151152153).

So let's consider theanine's effect on the human immune system:

  • The balance between different cytokines is regulated by this compound (244245246). Different cytokines, related to Th1 and Th2, can get out of whack in certain situations, and theanine positively affects that balance. Th1 and Th2 balance entail how well your immune system functions inside cells versus outside cells.
  • T-cell function - which is part of the adaptive immune system - may improve with theanine consumption (247248249). As always, this result is still preliminary, but, nevertheless, promising. Challenges to the immune system (such as substances that are non-self which are interacting with your biology) can subsequently better be reconized and remembered by your immune system. 

Dose? For immune-modulating purposes, the 150-milligram dose is perfect.

Verdict: good compound that is dosed adequately, but might be dosed pretty high when combined with other Neurohacker products. Almost all of the research points into the direction that this compound is beneficial for immune function.

 

10. Spirulina (Athrospina plantensis) Protein and Nucleotide Extract, 140 mg

Spirulina has become really popular lately, as a "superfood" and a compound that helps you detox (154155). The algae contain tons of different vitamins and minerals as well, and flavonoids, and other beneficial compounds.

Many people don't know, however, that spirulina also exerts an effect on the immune system (156157).

For instance, spirulina acts as an antioxidant, preventing the aforementioned "free radicals" that are created as a byproduct of energy production in your cells from creating harm. As a result, spirulina might affect the aging process as well as optimizing cell health and cell energy production over time.

And there's more:

  • Spirulina regulates cytokines so that they stay at healthy levels (158159160). The messenger function of cytokines is therefore improved. Depending on the cytokine, however, levels increase or decrease with spirulina consumption. 
  • Natural killer cells activity, part of the innate immune system, is increased (161162163164). Two cell functions, called “apoptosis” and “autophagy”, the ability of the body to clear damaged cells or recycle them, is potentially enhanced. The more damaged or unnecessary cells you have in your body, the less able to function. Replacing or recycling cells or cell components, in turn, increases your body’s ability to create new, optimally functioning cells.

    One study states:

    ". In a separate placebo-controlled, crossover study involving 11 healthy Danish subjects, we observed increased mRNA expression of the NK cell marker NKG2D by 37% (p = 0.02) and by 55% (p = 0.0003) after administration of Immulina® (200 mg and 400 mg per day, respectively) for seven days. The mRNA expression of the NK- and T-cell marker perforin increased by 75% (p = 0.008) after administration of 400 mg Immulina® per day. Both markers displayed significant dose-dependent effects (p = 0.0003 and p = 0.02, respectively)." (163)

    In plain English, the Natural Killer cells (NK) increase your body's ability to identify non-functioning and to clean them up before problems arise. Everyone has non-functioning cells that need to be replaced or recycled in their body, but, increasing this process leads to better overall health and a better functioning immune system.

    In the study listed above, 200-400 milligrams were used, so to me, it's likely that 140 milligrams in Qualia Immune also has an effect, knowing that many other supporting and synergistic compounds are included.
     

The dose is okay at 140 milligrams. Knowing it's an extract and not the original compound corrects somewhat for the lower dose though.

Verdict: great compound that almost certainly has positive effects for the immune system. Dose could be slightly higher but in combination with all other ingredients in this stack, spirulina is a great addition!

 

11. Cranberry Fruit Extract, 120 mg

Who doesn't love some cranberry fruits?

And yet, many people are under consuming berries despite their great health benefits (165166167).

Hence, it's unsurprising that berries also have benefits for the immune system:

  • Cranberries enhance the function of T cells. In one study, consuming 450 millilitres of cranberry juice per day led to a whopping almost 500% increase in "γδ-T cells" (168). 
  • Reasonably strong evidence exists that cranberry modulates the immune system through your gut (169170171172173). As a result, your gut microbiome improves so that a higher percentage of healthy bacteria colonize your gut due to protective properties in cranberry. Even in the colon and urinary tract functioning might improve so that the biome in these places is enhanced. 
  • Lastly, cranberry optimize cytokine functioning (174175176177). Remember that cytokines are partially responsible for the communication between different parts of the immune system.

The correct dose is harder to determine. 500-milligrams per serving is frequently seen online, but, I don't think you'd want to use very high doses for very long periods of time. 

Verdict: excellent ingredient that likely has many beneficial immune-modulating effects once more research into the compound is carried out.

 

12. LJ100®Eurycoma Longifolia Root Extract, 100 mg

"Tongkat Ali", or Eurycoma Longifolia, has been a staple in the natural health community for quite some time now.

For a long time, the compound was used as a "testosterone booster", but research on that benefit is flimsy.

The good part? Let's have a look:

  • Eurycoma Longifolia almost certainly has some stress mediating effects, thereby potentially giving you a more favorable hormonal profile (178179180181182). In one study, Eurycoma Longifolia supplementation led to lower cortisol levels in participants. Lower cortisol levels were intertwined with less tension, anger, and confusion, if you were stressed. Testosterone levels also increased. In another study, Eurycoma Lonifolia was combined with a multivitamin and led to better emotional health, well-being, and social functioning. Having a long history in Chinese medicine, these resiliency-increasing effects are perhaps best proven right now, and not the long lists of alleged benefits attributed to this compound right now - against anything from sexual dysfunction to countering malaria.
  • In a way, Eurycoma Longifolia also leads to a generalized, full-spectrum enhancement of the immune system (183184185186187). The result also translates into better general health because participants improved their gym performance in a study. Both endurance and strength improved. Cytokine levels are also affected. Lastly, the compound may improve the aforementioned process called "apoptosis" - the ability to kill old/unwanted/unhealthy cells. Again, everyone, even the healthiest people have some non-functioning cells inside their body. Enhancing your body’s ability to clear out cells and recycle them will improve many aspects of your health, including immune function.

The 100-milligram dose reasonable and slightly lower than what many studies use. Having said that, a higher dose probably won't work better and might be overkill long-term, as many studies only supplement with the compound less than a few months.

Verdict: great addition, Eurycoma Longifolia has very nice robustness and resilience-enhancing effects and increases general functioning of the immune system.

 

13. Broccoli Sprout Powder, 100 mg

Broccoli sprouts? Yes! These sprouts have even become famous for their health promoting effects and can be bought in many supermarkets today.

Sulforaphane is one famous compound in broccoli sprouts (188). This sulforaphane compound may be responsible for regulating proper cytokine function, thereby preventing your immune system from going haywire.

Also, broccoli sprouts may:

  • Decrease enhance the overall health capacity, such as regeneration, repair, and recovery (189190). In one study, consuming 30 grams of broccoli sprouts per day significantly optimized levels of "IL-6" and "C-reactive protein". To simplify that statement, think about Wolverine’s ability to repair compared to a healthy human: if you’re doing great, it doesn’t mean you cannot do even better. Now, Qualia Immune might not give you “Wolverine-like repair capacity” but it might enhance your recovery ability as a healthy human being.
  • Believe it or not, but, the sulforaphane compound also influences mitochondria function (191). Recall that the mitochondria are the "energy-generating factors of your cells". Many people don't know that the mitochondria also play a role in the immune system, specifically in cell defence (192193). If you have few or small mitochondria, your immune system might thus also work less well. The sulfur in broccoli sprouts may protect your mitochondria, thereby enhancing their function, especially during aging.

The dose? Well, I'd like to have seen a slightly higher dose than 100 milligrams, especially given that broccoli sprouts are a regular plant-based compound and not a spice or herb. 

Spices and herbs are more dangerous to put into the human body at higher doses for longer periods of time, in my opinion. 

Especially given the fact that many studies use 30 or 60 grams of broccoli sprouts, 100 milligrams, even under the assumption that an extract is 10 times as potent, seems to be dosed low.

Verdict: unique compound that benefits mitochondrial function and lowers excess inflammation, in addition to many other benefits I've not considered in this blog post. Even given the many other compounds found in Qualia Immune, I'd up the dose of these sprouts, if possible.

 

 

14. N-Acetyl-L-Cysteine, 100 mg

N-acetyl-l-cysteine? Do I know this compound? Absolutely, cysteine is an "amino acid" - a building block of proteins. Cysteine is generally known for its effects on detoxification.

Meats, lentils, oatmeal, and eggs are some great sources for cysteine.

Let's consider all of the effects:

  • As stated, cysteine plays a major role in your body's ability to detoxify (194195196197198). Detoxification is very important for health, and yet, many people even in the online community falsely believe that there's nothing you can do to aid or detract from detoxification processes. Nothing could be further from the truth though. Heavy metals and cyanide are processed better by your body with sufficient cysteine, for instance, as well as many other toxins. Nevertheless, you can probably easily imagine that if your body detoxifies quicker, due to good health or high quantities of essential nutrients, many processes in the human body perform better. As a result, immune function also goes up.
  • Once more, consuming adequate cysteine also optimizes your immune response (199200201202203). As a result, the fitness of your immune response goes up, because the natural defenses of the immune system do a better job. The body is better able to identify substances that are “non-self” and will less likely see the body’s own cells as a problem.

These effects are observed in many different studies, although, multiple high-quality studies with human participants are lacking, as always. Animal studies do confirm this picture though. For this reason alone, adding cysteine to an immune-supporting supplement is justified.

Combining theanine and cysteine also has potentially added benefits, which Neurohacker does (203).

What do I think about the dose? Perfect! Heck, I would have given a negative judgment if a very high dose of cysteine were included here. Why? Simple: if you're going to take this compound day in, day out, for months or years, you will create imbalances if one amino acid is structurally supplemented in the absence of all others.

Foods always contain a combination of amino acids. If a supplement gives you a high amount of just one amino acids, it's no bueno.

Verdict: perfect that cysteine is added. Adding this compound to an immune-support supplement is 100% justified. Dose also great.

 

 

15. Panax Ginseng Root Extract, 100 mg

"Panax Ginseng", which can be translated to "true ginseng".

You can probably guess why this ingredient is included by Neurohacker. And, yes, you guessed correctly: ginseng, especially true ginseng, is known for its resilience-promoting effects.

You probably know that many people in today's society are chronically stressedStress management helps but ginseng gives you an additional edge! Let's explore this plant "medicine" some more:

  • Ginseng almost certainly lowers fatigue and increases stress tolerance (204205206). Evidence exists for both the American and Asian (Korean) true ginseng and is probably a bit stronger for the latter version. There are indications that in some people, the energetic capacity of the cells in the body increases. Physical performance does usually not increase, as far as studies show right now. Nevertheless, once your cells create more energy it's likely that immune function also becomes better. And, exactly that effect is found:
  • Your immune system performs better on ginseng (207208209210211). For instance, there is some evidence suggesting that you become more resilient by consuming ginseng. Ginseng aids both the innate as well as the adaptive immune system and their interaction. While not going into extreme detail here, I was really surprised how many different moving parts of the immune system are influenced by ginseng. Ginseng may also act as an antioxidant, lowering the side-effect of "free radicals" that are created due to energy production.

The 100-milligram dose is also excellent.

Verdict: amazing ingredient that has many all-round benefits for making your immune system more effective and efficient. Great choice by Neurohacker! I even wonder whether they should include more of these adaptogens, but, some are already included in other products such as Qualia Mind (Rhodiola Rosea) and Qualia Life (Aswagandha)

 

 

16. LC-Plasma Lactococcus lactis strain Plasma (heat-killed), 50 mg

Probiotics, great! 

Looks like Neurohacker has done their job exceedingly well because they also selected this probiotic for a specific strainMany cheaper probiotics on the market don't categorize the prebiotic for specific strains, even though different strains can have wildly different outcomes in scientific studies.

Hence: kudos to Neurohacker!

You normally ingest this strain through fermented health products, such as buttermilk.

Fortunately, there's some decent research carried out on L. Lactis as a probiotic. Let's explore that research:

  • In animal studies, L. Lactis optimizes the repair & regeneration responses and the levels of cytokines (212213214215216217). These mechanisms are extremely complex though, but, the probiotic does probably support a healthier immune response and cytokine levels. Human studies are completely lacking in this area though.
  • In some weird way, this probiotic also alters the immune response (218219220221). In animal studies, immune tolerance in the gut is promoted and the body is probably better able to identify foreign compounds (“non-self”) or better deal with them. That process, in turn, is related to the allergic responses which are also tied to cytokine modulation I talked about previously. The only thing I'd like to see is more human intervention studies on this topic. Several tissues/systems seem to be able to be positively affected by L. Lactis, such as the gut, airways, and more.

The dose is close to doses used in medical studies so it's perfect (222223).

 

**Update: Neurohacker e-mailed me on how the Lactococcus lactis strain they've included is heat skilled and has independent human studies backing their use. I'll go through these studies soon and update my assessment again. Neurohacker's argument is that the dose used in this supplement is the exact same as used in human studies**

 

Verdict: interesting compound whose addition to an immune product can be justified. I'd like to see more high-quality human research though, although, risk of any adverse effects is probably extremely low because it's a simple substance that many already ingest through their diets. Dose is good!

 

17. Maritech®Fucus vesiculosus Extract, 50 mg

"Fucus vesiculosus", or, just "bladder wrack", "sea oak", or red fucus" in plain English. And no, I didn't know these terms in plain English either!

Suffice it to say that Fucus vesiculosus is a seaweed that exhibits health effects. Neurohacker themselves state that they've included this seaweed because of an ingredient called "fucoidan".

Let's look at some of the effects of fucoidan:

  • First of all, fucoidan helps recognize antigens and several parts of the immune system such as macrophages, natural killer cells, and others (224225226227228). Seasonal immune health in the fall and winter is thereby promoted, for instance, and the immune system becomes more resilient and is prepared for challenges to a greater extent.
  • Once more, this compound may improve the process of “apoptosis” and “autophagy” (229230231232233). In other words, this compound seems to have benefit in that it specifically targets non-functioning cells for cleaning and not all bodily cells. Therefore, fucoidan can also be used to keep your immune system younger, working more efficiently & energetic, and optimizing natural defencess. 

Moreover, fucoidan removes older/obsolete cells through natural killer cells and macrophages, which eat these cancer cells and clean them.

The dose is harder for me to judge, but, using this compound for prevention, the 50 milligrams of extract is probably great.

Verdict: Highly promising compound that has an all-round effect in making you even more resilient and makes many parts of the immune system function more efficiently. Great find by Neurohacker.

 

18. Fucorich®Undaria pinnatifida Extract, 50 mg

Another very exotic compound that you might not have heard about, right? Well, maybe not! Undaria pinnatifida is simply "wakame", a pretty common seaweed. 

Why this compound? Well, it turns out Undaria pinnatifida extract also contains fucoidan! Hence, many of the benefits I've attributed to fucoidan in the last section can also be attributed to this wakame extract.

in fact, the product, Fucorich® Undaria pinnatifida extract, has been standardized towards maximum fucoidan content - 50% in this specific case. Hence, there's very little meaningful for me to say, that hasn't already been said before.

Verdict: a second seaweed ingredient targeted towards increasing fucoidan dose. Same benefits as the previous (#16) ingredient I considered. Once again, great choice by Neurohacker.

 

 

19. Polygonum Caspidatum Root Extract (95% Resveratrol), 25mg

Resveratrol has taken the world by storm in the last decade (231232233). The compound has anti-oxidant effects, can enhance regeneration and repair, among others, within the healing process. Resveratrol might also help your immune system clean up old, damaged, or non-functioning cells.

Literally, hundreds of studies have been carried out on resveratrol in the last years.

While resveratrol can be found in dark chocolate and red wine, for supplements it's almost always sourced from Japanese knotweed (Polygonum Caspidatum). 

Why include this compound? Well, resveratrol also affects the immune system! Let's find out how:

  • The effect of resveratrol on the immune system is extremely complex (234235236237). Levels of different immune cells change, for instance. Cytokine levels can also become healthier with resveratrol consumption. As a result, resveratrol may increase your body’s ability to differentiate between the self and non-self, in terms of compounds in the body. Almost every part of the immune system seems to be influenced, from Natural Killer (NK) cells to the T-cells of the adaptive immune system. It's also possible that resveratrol has anti-aging effects, which is a welcome addition for many!
  • Remember that your mitochondria and immune system also interact? Resveratrol can keep your mitochondria healthy by stimulating a process called "autophagy" (238239240241242). "Autophagy" is the self-cleaning of mitochondria and cells that have become sub-optimal. Over time, that process is actually very healing to your overall health - much of autophagy normally occurs at nighttime. Autophagy is always an ongoing process but things like deep sleep, fasting and consuming resveratrol can increase the intensity of the process. You can basically envision autophagy to be akin to a "quality-check" of your car - if your mechanic doesn't replace damaged parts in your car once in a while, you'll end up with problems over time! The same is true, as stated earlier, for “apoptosis”!

The dose looks good. Neurohacker themselves state that they mainly use the compound for "hormetic" reasons. Hormesis is the principle that temporary stress can cause long-term beneficial adaptations.

Verdict: solid compound that helps the immune system work more efficiently. The dose is low compared to common resveratrol doses found online but Neurohacker is probably playing this one on the safe side - high doses of resveratrol are hard(er) to handle for people with chronic health conditions!

 

Overall Verdict: What Do I Think About This Supplement's Quality?

Having taken a very deep dive into the research regarding different parts of the immune system and the effects all 19 ingredients found in Qualia Immune have on them, I will say that I'm impressed.

Because this is my first article regarding the immune system, I haven't achieved the mastery that I can apply to other areas of health (yet), in this case. Therefore, I've taken more of a fact-checker position - an honest one - and verified the formulation technique of Neurohacker against the existing literature.

My personal conclusion?

After random sampling of some of Neurohacker's formulation techniques against the scientific literature, they are surprisingly accurate. Initially, I was even skeptical of a supplemental strategy to enhance the immune system at many different levels.

Now I no longer am skeptical, and I fully think this approach can work.

Neurohacker and I might slightly disagree about how strong the supporting evidence is, but, I think we do agree that the science all points in the same direction. Much more research is also needed, with high-quality studies using human participants, to confirm what many animal and foundational science (in vitro) studies conclude.

Nevertheless, you cannot always wait for high-quality science to arrive. If Neurohacker has to wait decades or even centuries for these studies to have been carried out, many people would not benefit from this product.

Hence, I like their approach, and generally, I think their intentions reflect the science of the immune system reasonably well. let's therefore conclude:

 

Finishing Thoughts: Vive La Révolution!

Neurohacker did it again...

Even though personally didn't feel anything on this supplement, I can really see how it's a potential game-changer over time for many.

When I used Neurohacker's Qualia Mind (the caffeine-free version) initially, I immediately fell in love. I understood that the supplement would be a game-changer for me.

And, after taking a deep dive through the science of Qualia Immune, I can see how this supplement is a game-changer for many.

What if you have your immune system function just a little bit better every day? What if you are already doing good in life but want to become more resilient and have your immune system function like an elite athlete instead of doing merely good

Qualia Immune is that potential game-changer for you (discount code FERGUS saves 15% in case you want to buy!). There's no risk in trying! 

(Again, this product is not aimed at treating or curing any disease. The product is aimed at lowering your stress levels, supporting your immune system, making sure your immune system is able to learn more quickly, clean up old and damaged cells, etcetera!)

So, Qualia Immune helps you go from good to great!

I can imagine the product is helpful in many situations. Maybe you're an elite athlete who is under tons of stress. In that case, you want your immune system to function at 100% at all times because you need every edge you can get. Or, perhaps you're working 70 hours a week as an entrepreneur or management consultant and want to be on the top of your game every single day.

In all those cases, an optimally functioning immune system will be perfect! So try Qualia Immune now, use discount code FERGUS, and get 15% off. The first bottle only costs $39 (without discount applied) if you choose a subscription. Subscriptions can be cancelled any month. 

So why do I say "Vive Le Révolution!"? Simple: Neurohacker has developed a new product category in biohacking, in the same way, they did with "nootropic stacks" a few years ago. This time Neurohacker developed the "immune stack".

I personally think the immune stack will start a long road of development of immune-supporting products, by both Neurohacker and their competitors, that will last forever.

Tying that statement back to the introduction:

Neurohacker has created a new road in human evolution, with new opportunities, and possibilities that didn't exist in 2019. For that achievement, Neurohacker deserves our compliments!

 

Note On Recommending This Supplement.

I'd only recommend this product as a supplement to take your immune system from good or great to greater. If you're drinking tons of soda, never moving, and eating junk food often then I would not recommend you take this supplement. Instead, get your basics in order first. Once you achieve good to great general health, you might include Qualia Immune to take your immune system functioning over the top!

 

Items Mentioned:

  • Qualia Immune - use discount code FERGUS to save 15%
  • Qualia Life - use discount code FERGUS to save 15%
  • Qualia Nootropic (Mind & Essentials) - use discount code FERGUS saves 15%

 

Found This Interesting? Then You Might Like:

 

This is a post by Bart Wolbers. Bart finished degrees in Physical Therapy (B), Philosophy (BA and MA), Philosophy of Science and Technology (MS - with distinction), and Clinical Health Science (MS), and is currently a health consultant at Alexfergus.com. 

 

 

 

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